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Tuesday

 

The Genetics of MS





























 MS and Your Genes. Thomas Tolstrup / Getty Images

Immune System Genes Linked to MS

Your genes are an important factor in whether or not you are at risk for developing MS, as supported by both family and scientific studies.

Family Studies as Proof that Genes Play a Role in MS
In the general population, there is a 1 in 750 chance (0.1 percent) chance that a person will develop MS. But the identical twin of a person with MS has approximately a 25 to 40 percent chance of developing MS, and the sibling or child of a person with MS has a 3 to 5 percent chance.


Scientific Studies as Proof that Genes Play a Role in MS
A 2007 study published in the New England Journal of Medicine found a new genetic risk factor for multiple sclerosis (MS). The study shows that people who have certain variations of two different genes involved in the immune system (IL7RA and IL2RA) are more likely to have MS than people without these mutations.

IZ7RA and IL2RA are proteins that guide the actions of one type of immune cell (T cells). As genes control how proteins are made in the body, changes in protein type represent a difference in genetics.

The MS-related version of the protein may contribute to MS by guiding those immune cells to attack the nervous system, which leads to demyelination and lesions on the brain and spinal cord. This damage, in turn, causes the huge variety of MS symptoms. Interestingly, IL2R mutations have been associated with type 1 diabetes and Graves’ disease, also autoimmune disorders.

A number of other studies have supported a link between MS and the genes that control a person's immune system. The tricky part is that there are likely a vast number of genetic changes, estimated to be 50 to 100 by the National MS Society, that determine a person's risk of developing MS and if they do develop MS, how severe it is.


Analyzing the MS genetic data is complicated and time-consuming, but worthwhile, especially if it can better tailor MS therapies.

Bottom Line
It's important to understand that while genes do play an important role in the development of MS and potentially the course it follows, they are not everything. In other words, MS is not a directly inherited illness, so there is no guarantee that you will or will not get it based on your family history (or your individual genetic code).

Instead, the manner in which MS develops and manifests in a person is likely complex, involving a dynamic between a person's genes and their environment. For example, a series of genetic changes may make a person more vulnerable to developing MS when exposed to a certain environmental trigger, like a virus (although, we do not know those precise triggers yet).

Story Source: The above story is based on materials provided by VERYWELL
Note: Materials may be edited for content and length
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