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Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
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Monday

 

Remyelination therapies: a new direction and challenge in MS







































Image Source: MULTIPLESCLEROSISNEWSTODAY

Abstract
MS is characterized by inflammatory activity that results in destruction of the myelin sheaths that enwrap axons. The currently available medications for MS are predominantly immune-modulating and do not directly promote repair. White matter regeneration, or remyelination, is a new and exciting potential approach to treating MS, as remyelination repairs the damaged regions of the central nervous system. A wealth of new strategies in animal models that promote remyelination, including the repopulation of oligodendrocytes that produce myelin, has led to several clinical trials to test new reparative therapies. In this Review, we highlight the biology of, and obstacles to, remyelination.
Story Source: The above story is based on materials provided by NATURE
Note: Materials may be edited for content and length


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