FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Monday

 

In MS, Disease Duration, Lesion Load Predict Relapses and Disability Progression







































Image Source: MULTIPLE-SCLEROSIS-RESEARCH

Baseline disability, age, and MS disease duration may help predict 6-month confirmed disability progression in patients with relapsing-remitting MS, according to a post-hoc analysis of the TRANSFORMS trial (ClinicalTrials.gov: NCT00340834).

The results of the 36-month follow-up study were presented at the 2017 Consortium of Multiple Sclerosis Centers Annual Meeting, May 24-27 in New Orleans.

TRANSFORMS was a 12-month, double-blind, randomized, phase 3 study of fingolimod 0.5 mg/d vs intramuscular inferferon beta-1a in patients with relapsing-remitting MS. In the extension study, patients who received interferon beta-1a were switched to fingolimod. In the current study, the team of investigators, led by Aaron Boster, MD, of Ohio State University in Columbus, sought to assess the ability of clinical parameters at baseline through month 12 to predict MS relapse and disease progression in months 12 through 24 and 12 through 48.

A total of 1292 patients were included in the TRANSFORMS study (month [M] 12-24=973; M12-48=778). In both the short and long term, relapse was predicted by a combined clinical occurrence of at least 1 gadolinium-enhancing lesion or at least 2 T2 lesions and at least 1 confirmed relapse (M12-24: odds ratio [OR] 2.776; 95% CI, 1.649-4.674, P <.0001; M12-48: OR 3.703; 95% CI, 2.158-6.356, P <.0001) or the number of confirmed relapses from baseline to month 12 (M12-24: OR 2.24; 95% CI, 1.751-2.866, P <.0001; M12-48: OR 2.297, 95% CI 1.753-3.009, P < .0001).

Factors that predicted 6-month confirmed disability progression in months 12-48 were baseline Expanded Disability Status Scale score (OR 1.44; 95% CI, 1.244-1.668, P <.0001), MS disease duration (OR 1.045; 95% CI, 1.009-1.082, P =.0131), and age (OR 1.033; 95% CI, 1.010-1.057, P =.005).

Story Source: The above story is based on materials provided by NEUROLOGYADVISOR
Note: Materials may be edited for content and length


Go to Newer News Go to Older News