FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Sunday

 

'Resetting' immune system may achieve long-term remission




























Researchers suggest that a combination of high-dose chemotherapy and stem cell transplantation could lead to long-term remission of RRMS.


More than two thirds of patients with relapsing-remitting multiple sclerosis, who were treated with a combination of high-dose chemotherapy and stem cell transplantation, have been in remission for 5 years, according to the results of a small clinical trial.

Study co-author Dr. Richard Nash - of the Colorado Blood Cancer Institute and the Presbyterian-St. Luke's Hospital in Denver, CO - and colleagues recently reported the final results of their phase II trial (called HALT-MS) in the journal Neurology.
Relapsing-remitting multiple sclerosis (RRMS) is the most common form of MS, accounting for around 85 percent of all diagnoses.

MS is a disease whereby the immune system mistakingly attacks myelin - the fatty substance that protects nerve fibers in the central nervous system - and the underlying nerve fibers. This interferes with signaling between the brain and spinal cord.

This disruption can cause muscle weakness and stiffness, problems with walking and balance, and chronic pain. People with MS may also experience fatigue, dizziness, cognitive deficits, and vision problems.

In RRMS, patients experience inflammatory attacks on myelin and the nerve fibers - referred to as "relapses" - and symptoms of MS arise. These relapses are followed by periods of complete or partial remission, whereby some or all of the symptoms disappear.

There is no cure for RRMS, but there are a number of medications that can help patients to manage relapses and symptoms.

However, the results of the new study suggest that one-time high-dose immunosuppressive therapy (HDIT), followed by autologous hematopoietic cell transplantation (HCT), may lead to long-term remission for patients with RRMS.

Most RRMS patients in remission 5 years after HDIT/HCT
The goal of HDIT/HCT is to remove all MS-causing cells from the body.

The therapy involves collecting a patient's blood-forming stem cells, before treating them with high-dose chemotherapy to destroy their immune system. The blood-forming stem cells are then returned to the patient, effectively "resetting" their immune system.

In 2014, Dr. Nash and colleagues reported the 3-year results of their phase II clinical trial for HDIT/HCT. The trial involved 24 patients with RRMS aged between 26 and 52. All patients were using currently available medications for their condition, but none were experiencing a reduction in relapses or disease progression.

For the trial - funded by the National Institute of Allergy and Infectious Diseases (NIAID) - each patient received HDIT/HCT. The team found that almost 80 percent of patients experienced no relapses, worsening of disability, or new brain lesions in the 3 years following treatment.

In the new study, the researchers assessed the same group of patients 5 years after HDIT/HCT. They found that 69 percent of patients had still not experienced relapses, disability progression, or new brain lesions since the treatment.

Importantly, none of the patients had used any RRMS medications since treatment with HDIT/HCT.

Reported side effects of HDIT/HCT included cytopenias (a reduction in blood cells) and infections. Three patients died during the 5-year follow-up, but the researchers say that their deaths were not related to their treatment.

Story Source: The above story is based on materials provided by MEDICALNEWSTODAY
Note: Materials may be edited for content and length
Click here to read more


Go to Newer News Go to Older News