FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Monday

 

Late-Onset MS Patients More Likely to Progress Quickly to Disability, Study Says

























People with late-onset MS tend to more rapidly rise in disability scores than younger patients with early onset MS, according to study in MS patients in Kuwait that compared their scores during follow-up consultations.

Typically, the first symptoms of  multiple sclerosis occur between the ages of 18 and 40, with an estimated 20 percent of  all MS patients experiencing first symptoms after the age 40.  But late-onset MS appears to be increasing in the general population, the researchers said in their study, “Is Time to Reach EDSS 6.0 Faster in Patients with Late-Onset versus Young-Onset Multiple Sclerosis,” published in the journal Plos One.

Later onset disease can also be a diagnostic challenge, since its clinical presentation and course seems to be different from those with earlier onset MS. Few studies have traced the natural progression of late-onset disease.

Researchers at various universities and hospitals in Kuwait gathered demographic and clinical information on MS patients — presentation at onset, disease duration, number of relapses, and expanded disability status scale (EDSS) scores — using data from the Kuwait National MS Registry, established in 2010.

Their focus was time from baseline to sustained disability, defined by an EDSS score of 6.0. This score has been indirectly associated with disability progression, and is defined as the need for “intermittent or unilateral constant assistance [cane, crutch, or other] … to walk about 100 meters with or without resting.”

In total, the study included 99 (10.7%) late-onset patients with a median age of 45.9, and 804 (89.3%) early onset patients, whose median age was 26.6.

EDSS analysis during follow-up found that 19.2% of the late onset group and 15.7% of early onset patients reached EDSS 6.0.  Late-onset MS patients reached this higher disability level much more quickly — a median of 6.5 years  — than patients diagnosed with MS earlier in life, a group that took a median of 12.8 years to reach 6.0 on the EDSS scale. This difference, the researchers said, represented a 3.6-increased likelihood of late-onset patients reaching EDSS 6.0 compared to early onset patients.

Male gender and spinal symptoms at onset of MS were also significantly associated with increased risk, 1.85 and 1.47, respectively, of reaching EDSS 6.0 in a shorter time.

During this follow-up, a higher proportion of  late-onset patients (26.3%) progressed to a more severe disease state — secondary progressive MS — compared to those with earlier onset (17.8%). Researchers also reported that spinal cord disease symptoms at onset were more prevalent among late-onset (46.5%) than early onset (32.3%) patients.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length


Go to Newer News Go to Older News