FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Wednesday

 

Oral MS Drug Completes Phase 2 Trial

















































Image Source: REDHILLBIOPHARMA

A proof-of-concept phase 2a study of a fixed oral dose RHB-104 for relapsed-remitted multiple sclerosis (RRMS) was recently completed, with results expected to be released later this year.

The open-label CEASE-MS enrolled 18 patients with RRMS to evaluate the safety and potential efficacy of RHB-104 as an add-on therapy to interferon beta-1a. RHB-104 is a proprietary, and potentially groundbreaking, oral antibiotic combination therapy, with potent intracellular, anti-mycobacterial and anti-inflammatory properties.

During the study, participants were given RHB-104 for 24 weeks, and were evaluated for an additional 24-week follow-up period where they received interferon beta-1a without the RHB-104 add-on. The study analysis is currently ongoing, and the top-line final results are expected to be announced in the fourth quarter of 2016, subject to completion of review requirements and of the clinical study report.

Back in March 2016, RedHill Biopharma announced top-line interim results after completion of the 24-week RHB-104 treatment period, which demonstrated positive safety and efficacy signals that further support clinical development. The top-line interim results demonstrated an annualized relapse rate at 24-weeks of 0.288 in the modified intent-to-treat (mITT) population, and 0.0 in the per-protocol (pp) population, which compared favorably with previously reported pivotal studies of interferon beta-1a therapies Avonex (0.67) and Rebif (0.87-091).

The study showed that 88% of the mITT patients and 100% of the PP patients were relapse free at 24 weeks, which compared favorably with previously reported pivotal data on the use of Rebif (75%) in comparison with Avonex (63%) as standalone first-line therapies. None of the participants relapsed after week 8 of treatment.

Currently, RHB-104 is undergoing a phase 3 trial for Crohn’s disease in the United States, Canada, Europe, Australia, and Israel.

Story Source: The above story is based on materials provided by SPECIALTYPHARMACYTIMES
Note: Materials may be edited for content and length


Go to Newer News Go to Older News