FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Wednesday

 

Relapses Prevented in MS Mouse Model





























Researchers at the University of Heidelberg, Germany, recently showed that peripheral blood cells loaded with a drug that resembles the myelin protein are able to inhibit harmful immune responses and prevent relapses in a mouse model of relapsing-remitting MS.

The findings were described in the study “Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis,” and published in the Journal of Translational Medicine.

MS is a chronic inflammatory disease, characterized by the degradation of the myelin sheaths surrounding the nerve cells. Since the immune system is known to play a crucial role in this process, there have been many attempts to control the disease’s path of development by inhibiting the immune response. However, the approaches are commonly unspecific, and lead to side effects due to a generalized immunosuppression.

In previous studies, the authors had managed to prevent the experimental autoimmune encephalitis (EAE) mouse model for MS, by previously injecting the animals with dendritic cells (DCs) loaded with myelin basic protein (MBP), a brain derived autoantigen. Treated with a chemotherapeutic agent – mitomycin (MMC) -, showed that autoantigen-loaded, MMC-treated DCs could be used as a protective vaccine.

Recently, the research team, led by Peter Terness, addressed whether the approach could be used as therapy against an ongoing disease. To avoid the risk of exacerbating the disease with autoantigens, the MBP was switched by a random copolymer of amino acids, called “glatiramer acetate” (Copaxone) which is a drug approved for the treatment of relapsing-remitting MS that highly mimicks MBP.

Because never before exposed DCs are stimulatory cells, even after being rendered suppressive by MMC treatment, they regain stimulatory capacity which led investigators to address if DCs could be replaced by peripheral blood cells (PBMC), which are less immunogenic and much easier to prepare.

Results revealed that injection of PBMCs loaded with Copaxone and induced with MMC was able to inhibit the harmful autoreactive immune response and prevent further relapses in mice models of MS – possibly by the increased infiltration of regulatory T cells that secrete specific cytokine molecules known to suppress other immune cells. Importantly, the general immune responses were not affected.

The study concluded: “Donor MIC [MMC-induced] cell therapy is currently being implemented in living donor kidney transplantation. The findings of the present study, although not clarifying all mechanistic questions, constitute a sound basis for a clinical phase I study with MICCop cells in patients with MS.”

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length
Click here to read original article


Go to Newer News Go to Older News