FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Monday

 

Cognitive Difficulties Known to MS Traced to Problems in Nerve Cell Activity in Hippocampus
























In a study published in the International Neurology Journal, researchers showed that cognitive deficits, such as memory problems, in a rat model of multiple sclerosis (MS) are mirrored by changes in synaptic transmission and plasticity in the hippocampus, a brain region crucial for memory processing. The findings advance the understanding of disease mechanisms affecting cognition in MS patients.

Cognitive deficits such as learning and memory dysfunction are common in MS, affecting 40 percent to 60 percent of patients. While earlier studies reported that brain inflammation might alter the generation of neuroplasticity, particularly at the synaptic level, not much is known about the mechanisms leading to such changes.

Studies also show that the hippocampus is affected by nerve cell death in MS patients. Using the well-characterized experimental autoimmune encephalomyelitis (EAE) animal model of MS, researchers at Arak University of Medical Sciences, Iran, used recordings of nerve cell activity in live rats to study the impact of disease on memory processes.

Using behavioral tests to study memory processes in EAE animals can be challenging, since these mice often have motor symptoms that might impact the outcome of such tests. Instead, information of how signals are transmitted at neuronal connections, synapses, as well as long-term potentiation — the mechanism underlying changes in synaptic strength, and hence neuronal plasticity — can be used to understand the mechanisms behind changes in memory function.

The study, “Changes in Synaptic Transmission and Long-term Potentiation Induction as a Possible Mechanism for Learning Disability in an Animal Model of Multiple Sclerosis,“ showed that the EAE mice had deficits in synaptic transmission and long-term potentiation in the hippo­campus.

Further analysis, using a method called paired pulse inhibition, capable of detecting differences in effects of neurotransmitter release, showed that EAE changed the signaling by neurotransmitter GABA, the main inhibitory neurotransmitter in the brain.

The team concluded that the GABA-B receptor, one of two main receptor types for the neurotransmitter, had increased efficacy in the hippocampal region of the rats, explaining why the synaptic transmission and long-term potentiation was lower in the EAE-affected animals.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length

Labels: ,



Go to Newer News Go to Older News