Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
You'll get FREE Breaking News Alerts on new MS treatments as they are approved

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
Medical Director-Rocky Mountain MS Center

Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore

This page is powered by Blogger. Isn't yours?



Gilenya (Fingolimod) Shown to Benefit Neurons as Well as Immune System

The immune system-suppressing multiple sclerosis (MS) drug fingolimod also has potentially beneficial effects on the nervous system, according to a recent study, “The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration.“  The article appeared online March 12 in an early version of the journal Experimental Neurology.

Fingolimod is a relatively new medication for MS, and researchers designed the drug to target the immune system. In MS, the immune system is overactive and damages myelin, the substance that wraps around neurons and allows them to communicate efficiently. Increasing evidence suggests that neurons are also damaged, and that the axons that extend from these brain cells and connect them to one another may be lost. Clinical trials on fingolimod have shown that the drug reduces the rate of relapses in relapsing-remitting multiple sclerosis (RRMS) patients by approximately 50 percent over two years.

Sofia Anastasiadou and Bernd Knöll from the Institute of Physiological Chemistry, Ulm University, Germany, explored the possibility that fingolimod has additional effects on  the nervous system, which may complement its influence on suppressing the immune system.

The researchers grew mouse neurons in a dish (in vitro) that had been taken from a region of the brain that controls movement, known as the cerebellum. They then added fingolimod to the cells and looked for changes in neurons, using a variety of standard laboratory measurements.

The team observed that fingolimod had several different effects on neuron growth. It caused extensions — known as neurites — to grow from the cells, and increased several molecules that indicate axon growth.

To understand whether fingolimod might not only influence the development of neurons but also repair the damaged nervous system, researchers next gave the drug to mice with a damaged facial nerve. Fingolimod improved the regeneration of axons in the facial nerve, and its actions seemed to depend on the activation of a transcription factor (gene regulating molecule) called serum response factor (SRF), which is known to protect neurons.

The authors concluded, “[Fingolimod] is now a routinely employed drug to treat multiple sclerosis. So far, [fingolimod]’s mode of action was believed to mainly involve sequestration of auto-reactive immune cells in lymph nodes. In this study, we demonstrate that [fingolimod] has direct actions on neurons including stimulation of a neuronal-plasticity associated gene.”

Fingolimod may have more beneficial effects in MS than previously believed, and could potentially be used to treat other neurological diseases or nervous system injuries.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length

Labels: ,

Go to Newer News Go to Older News