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Thursday

 

Can aerobic exercise alleviate flu-like symptoms following interferon beta-1a injections in patients with MS: STUDY








































Image Source: ACTIVEFOREVER


Abstract

Background:
Flu-like symptoms (FLS) are common side effects of interferon beta (IFNß) treatment, and may affect the willingness to initiate therapy, the long-term acceptability, and the adherence to the treatment. Case reports suggest that aerobic exercise is able to markedly reduce FLS following IFNß-1a injections in persons with multiple sclerosis (PwMS).

Objective:
To test the hypothesis that aerobic exercise can alleviate FLS following IFNß-1a injections in PwMS, and secondarily to examine whether or not fluctuations in circulating cytokines provide a mechanism that can explain a potential positive effect.

Methods:
Seventeen PwMS who frequently experience FLS following IFNß-1a injections completed four days of testing. On two of the testing days they completed 35 min of aerobic exercise on a bicycle-ergometer following IFNß-1a injection. On the two other testing days, no intervention took place following the injection. FLS were assessed pre-injection and 3 h, 5 h, 12 h and 24 h post-injection. Blood samples were taken pre-injection and 1 h and 3 h post-injection to determine levels of circulating interleukin 6 and 17 and IFNγ. The primary study endpoint was the comparison of the change in FLS severity from pre-injection to 5 h post-injection between days with injection alone and days with injection followed by aerobic exercise.

Results:
FLS severity change was significantly lower on days with exercise compared to days with rest. IL6 was significantly increased 3 h following IFNß-1a injection and exercise compared to 1 h post and pre and when compared to the resting condition. Participants reported no adverse events in addition to FLS during the study period.

Conclusion:
Data from this study suggest that moderate intensity aerobic exercise following IFNß-1a injections is safe and can alleviate the FLS severity in PwMS. Based on these results, 35 min of aerobic exercise should be encouraged for PwMS who often experience FLS following IFNß-1a injections.

Story Source: The above story is based on materials provided by JOURNALOFTHENEUROLOGICALSCIENCES
Note: Materials may be edited for content and length

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