FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Monday

 

Tecfidera Seen to Alter Anti-Inflammatory Profile in Immune Cells































Study looks at mode of action in a relatively new, delayed-release treatment for RRMS

Delayed-release dimethyl fumarate (Tecfidera) was recently approved for patients with relapsing-remitting multiple sclerosis (RRMS), although the mechanisms by which the drug exerts its action were not fully understood. A new study from the University Hospital Münster, Germany, shows that dimethyl fumarate alters the balance between subpopulations of T-cells to promote a more anti-inflammatory state.

The study, “Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis,” was published in the journal Neuroimmunology and Neuroinflammation.

T-helper (Th) cells of the Th1 type are believed to play an important role in inflammatory conditions and autoimmune diseases, and a classical paradigm states that an altered balance toward the Th1 subtype can drive immune-related disorders. Also, Th17 cells are believed to be involved in autoimmune diseases such as MS.

The study enrolled 15 patients, who were then treated with dimethyl fumarate for six months. The research team analyzed immune cells isolated from the patients before and after the treatment.

The researchers found that dimethyl fumarate treatment decreased the levels of the subclass of T-cells referred to as memory cells of CD8+ and CD4+ type. The team also noticed that among the cytokine-secreting CD4 memory cells, the proportion of Th1 cells were decreased by the treatment while Th2 cells were increased. The proportion of Th17 cells was not affected.

Considering the observed changes in T-cell populations, the team also analyzed the production of inflammatory cytokines in isolated CD4+ cells and noticed that the percentage of cells producing the Th1-associated cytokines IFN-gamma, GM-CSF, TNF-alpha, and IL-22 had decreased, mirroring the alterations in T-cell composition.

The data showed that dimethyl fumarate alters the proportions of different subsets of T-cells in MS patients, inducing a more anti-inflammatory profile in the immune cells. The change was brought on mainly by a reduction in memory T-cells and an altered Th1/Th2 balance.

The authors concluded that dimethyl fumarate treatment might be most beneficial to patients with a Th1-driven disease, and suggested that more research is needed to fully understand the effects of dimethyl fumarate in these patients.

Since memory T-cells are important for the maintenance of antiviral immunity, the team also suggested a closer monitoring of subsets of memory T-cells in MS patients to better detect immune-mediated adverse effects, such as progressive multifocal leukoencephalopathy (PML) — a rare brain condition associated with dimethyl fumarate treatment.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length

Labels: , ,



Go to Newer News Go to Older News