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Thursday

 

Comparison of energy consumption in different clinical forms MS with normal subjects (cohort study): STUDY





































Image Source: 3DSCANNERIMAGE


Abstract

Background:
Multiple sclerosis (MS) is one of the most common joint disorders that influence walking performance.

Objectives:
The objectives are to determine if energy consumption of three different clinical forms of MS differs from each other. Is there any difference between MS and normal subjects? Is there an association between the Physiological Cost Index (PCI) and the Expanded Disability States Scale (EDSS)?

Methods:
MS subjects (EDSS>4) were separated in three groups based on the Ashworth and Ataxia scales, including ataxic (n=16), spastic (n=15) and ataxic-spastic (n=14). In addition, 13 age-and-gender-matched healthy subjects were used as the control group. A Heart Rate (HR) Polar Electro Finland was used to record the heart rate during resting and walking. The energy consumption was measured based on PCI. ANOVA, MANOVA, Post-hoc Tukey analysis and Pearson correlations were used for statistical analysis (P<0.05).

Results:
There was a significant difference between the walking speeds of normal (76.05±5.70 m/min) with ataxic (36.78±12.68 m/min), spastic (34.45±16.32 m/min) and ataxic-spastic (27.21±14.76 m/min) groups (P<0.001). There were no significant differences between the resting HR and walking HR of four groups, and no significant difference between the PCI of ataxic, spastic and normal groups (P>0.1). The correlation between PCI and EDSS was 0.65 (P<0.001).

Conclusion:
The performance of the cardiovascular system in MS subjects was the same as normal subjects. Their energy consumption increased significantly due to a decrease in their walking speed. It seems that the weakness of muscles of the lower extremity and spasticity of knee extensors play a significant role in this regard.

Story Source: The above story is based on materials provided by SCIENCEDIRECT
Note: Materials may be edited for content and length

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