FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Thursday

 

Potential Mechanism in MS Pathogenesis Seen in Study






















Researchers point to changes in subsets of inflammatory T cells in untreated multiple sclerosis patients

Researchers found that a group of untreated patients with multiple sclerosis (MS) and patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) carry a specific group of hyperactivated immune cells, the inflammatory CD8+ T cells, suggesting a potential common mechanism contributing to disease pathogenesis. The study, “A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis,” was published in the Journal of Immunology Research.

The immune system carries a special group of immune cells, called CD8+ T cells, with key functions in regulating immune system responses during an infection. Notably, CD8+ T cells have been identified in central nervous system lesions of MS patients, where they were suggested to contribute to the pro-inflammatory environment.

MS is an immune-mediated disease of the central nervous system characterized by destruction of the myelin layer within nerve cells, leading to a wide range of neurological symptoms. Recent studies reported that some MS patients develop CFS/ME, evidenced by a significant impairment in patients’ physical activity as a consequence of severe fatigue.

Since immune dysregulation is a common feature of both CFS/ME and MS, researchers investigated the levels and maturation of CD8+ T cells in serum samples collected from 23 CFS/ME patients, 11 MS patients without any history of immunomodulatory therapy, and 30 non-fatigued controls. To identify the subsets of CD8+ T cells at different stages of differentiation, researchers used stage-specific monoclonal antibodies.

The team found that CFS/ME and MS patients exhibited a significant impairment in several subsets of CD8+ T cells, with MS patients showing a particularly significant differential expression of several surface receptors within subsets.

The findings suggest that untreated MS patients may carry hyperactivated inflammatory CD8+ T cells as a result of major deficits in the expression of receptors and adhesion molecules on subsets of this cell population. The same phenotype was observed in CFS/ME patients (although MS patients seem to carry more severe immune dysregulation), suggesting that these deficits are a potential underlying mechanism contributing to the pathogenesis of these diseases. Further studies with larger cohorts of patients are, however, necessary to confirm these preliminary findings.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length 
Click here to read original article

Labels:



Go to Newer News Go to Older News