FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Sunday

 

Impairing cognition with TNF-α

































Image Source: UOFMHEALTHBLOGS

Infection and neurodegenerative diseases, including multiple sclerosis, are associated with cognitive defects and both are associated with increased inflammatory cytokines, such as tumor necrosis factor–α (TNF-α), in the brain.
Because synaptic plasticity in the hippocampus is important for memory and cognition, Habbas et al. examined the effects of TNF-α on hippocampal glutamatergic synapses in mouse hippocampal slice preparations. Application of 600 pM of TNF-α, but not of a low concentration (60 pM), increased presynaptic activity as measured by the frequency of miniature postsynaptic excitatory currents (mEPSCs). This increase in mEPSC frequency induced by 600 pM TNF-α was absent upon preincubation of wild-type hippocampal slices with an antagonist of the NMDA-type glutamate receptor or in hippocampal slices from mice globally deficient in the TNF receptor (tnfr1–/–). Selective reintroduction of TNFR1 into astrocytes in tnfr1–/– mice rescued the synaptic plasticity–inducing effects of TNF-α on the hippocampal slices, indicating that TNF-α acted at astrocytes, which then signaled to the neurons to increase presynaptic activity. AT-EAE mice are a model of multiple sclerosis, and compared with control mice, AT-EAE mice exhibited impaired fear learning and memory, which correlated with increased TNF-α and an accumulation of microglia and leukocytes in the relevant region of the hippocampus. Hippocampal slices from AT-EAE mice showed an increase in mEPSC frequency that was blocked by treating the mice with the NDMA receptor antagonist. Analysis of fear memory in the AT-EAE model comparing control tnfr1–/– and mice in which TNFR was selectively restored in astrocytes confirmed that the astrocyte response to TNF-α contributed to impaired fear conditioning and memory. Because inflammatory responses are necessary for neuronal injury repair, yet also contribute to long-term neuronal dysfunction, this study suggests that it may be possible to selectively target pathological effects, such as impaired cognition, in neurodegenerative diseases without blocking the beneficial effects of inflammatory responses (see Osso and Chan).

Story Source: The above story is based on materials provided by SCIENCESIGNALING
Note: Materials may be edited for content and length

Labels:



Go to Newer News Go to Older News