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Saturday

 

The TH17-associated cytokine interleukin-26 regulates barrier function during neuroinflammation: STUDY





























Image Source: ROCHE



Abstract

Background:
The association between brain imaging abnormalities,
primarily brain atrophy, and cognitive impairment in patients
with multiple sclerosis (MS) is well documented. While a correlation
between optical coherence tomography (OCT) findings and
these abnormalities has been found, the relation between OCT and
cognitive impairment is less clear. Therefore, the aim of this study
was to investigate whether inner retinal layer thickness is associated
with cognitive impairment in patients with MS.

Methods
Prospective, single center, cross-sectional study.
Subjects underwent multiple cognitive tests consisting of the
Brief Repeatable Battery of Neuropsychological Tests, concept
shifting test, Stroop colour-word test and memory comparison
test. Individual test scores were corrected for age, sex and level
of education, transformed to Z-scores and 6 different cognitive
domains were formed. Patients were considered cognitively
impaired if they scored 2 standard deviations below the mean on
2 or more domains compared to healthy control subjects (HCs).
Spectral domain OCT measurements of the macular ganglion
cell-inner plexiform layer (mGCIPL) and peripapillary retinal
nerve fibre layer (pRNFL) were performed. Logistic regression
was used to investigate the association between retinal layer
thickness and cognitive impairment, with adjustment for potential
confounding.

Results:
112 patients (81 without a history of optic neuritis
(MSNON) and 31 with a history of bilateral optic neuritis
(MSON)) and 48 HCs were included in this study. 33 of 112
patients (29.5%) were classified as cognitively impaired. In
MSNON, cognitively impaired patients had a significantly lower
mean pRNFL thickness (79.68µm (SD 2.07) vs. 87.38µm (SD
1.40), P = 0.004) and mean mGCIPL thickness (76.53µm (SD
3.91) vs. 88.16µm (SD 1.47), P = 0.012) compared to cognitively
preserved patients. After correcting for age and sex a significant
inverse association between retinal layer thickness and
cognitive impairment was found for both pRNFL (OR 0.91
(95%CI 0.84 - 0.97), P = 0.007) and mGCIPL (OR 0.91 (95%CI
0.85 - 0.97), P = 0.003) thickness. In MSON, no significant association
was found between retinal layer thickness and cognitive
impairment.

Conclusion:
In MSNON patients atrophy of the pRNFL and
mGCIPL layers is associated with cognitive impairment. This
suggests that atrophy of these layers reflects the presence of global
brain damage associated with cognitive dysfunction in MS.

Story Source: The above story is based on materials provided by PROQUEST
Note: Materials may be edited for content and length

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