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Health Canada Approves PLEGRIDY™ (peginterferon Beta-1a) For Adults With Relapsing Remitting Multiple Sclerosis

PLEGRIDY™ is the first and only pegylated interferon administered once every two weeks for the treatment of MS

Today, Biogen Canada Inc. announces the Health Canada approval of PLEGRIDY TM (peginterferon beta-1a), which has been approved for the treatment of adults with relapsing remitting multiple sclerosis (RRMS) to reduce the frequency of clinical exacerbations and to slow the progression of disability. 1 PLEGRIDY™ offers a unique combination of demonstrated efficacy, a favourable safety profile consistent with the established interferon class, and an every two week dosing schedule. 1

"PLEGRIDY is the first interferon dosed once every two weeks, which reduces the frequency of relapses and slows the progression of disability in people living with RRMS," said Dr. Marcelo Kremenchutzky, Director of the Multiple Sclerosis Clinic in London, Ontario. "PLEGRIDY provides the safety profile we have come to expect from an interferon, with demonstrated efficacy and the added convenience of a reduced dosing schedule."

Multiple Sclerosis (MS) is a chronic, often disabling disease that attacks the central nervous system (CNS), which is made up of the brain, spinal cord and optic nerves. Symptoms result, at least in part, from when a person's immune system attacks the protective covering, or myelin, of the brain and spinal cord and interferes with the transmission of nerve signals between the brain, spinal cord and other parts of the body. 2

PLEGRIDY™ is a new molecular entity, resulting from the application of pegylation technology. Pegylation prolongs circulation time by: increasing molecular size resulting in a longer half-life, stabilizes the molecule by improving chemical stability and solubility for a longer shelf-life and shields from degradation and decreased immunogenicity. 3 This allows patients to receive an interferon treatment with less frequent dosing. Beta interferons, like PLEGRIDY™, are a commonly-used class of RRMS treatments which are thought to resemble the body's natural interferon that works with the immune system and helps regulate the body's immune response; however, the exact mechanism is not known. 1 It is thought that beta interferon can reduce (and might prevent) inflammation which can damage nerve fibres in MS. 4

"We are pleased that Health Canada has been responsive in listing another disease-modifying therapy for those with multiple sclerosis," says Sylvia Leonard, National Vice President, Programs and Services, MS Society of Canada.

 "This responsiveness means that Canadians with MS have a more diverse range of treatment options available to them to meet their needs and lifestyles.

Individuals with MS who are interested in exploring treatment options are encouraged to consult with their healthcare team to find the course that is most appropriate for them."

Story Source: The above story is based on materials provided by THESTREET
Note: Materials may be edited for content and length


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