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Sunday

 

Thoracic spinal cord lesions are influenced by the degree of cervical spine involvement in multiple sclerosis: STUDY























Image source: MEDICALPICTURESINFO

Abstract

Objective:
To determine whether cervical spinal cord lesions predict the presence of thoracic cord lesions in multiple sclerosis (MS) patients.

Setting:
Single MS Clinic, AZ, USA.

Methods:
All MS patients, with MRI studies of the brain, cervical and thoracic spine obtained during a single scanning session, were acquired during a 1-year period. Clinical, demographic and imaging covariates were used in a multivariate regression model to refine predictors of thoracic cord involvement.

Results:
A total of 687 patients were evaluated, and patients were excluded because of a diagnosis of other neurological disorders, not meeting the 2010 McDonald criteria for MS (n=222) or incomplete neuraxis imaging (n=339). The study cohort comprised 126 patients. There was an increase in the odds ratio (OR) of thoracic spine involvement when any cervical spine lesion was present (OR=6.08, 95% confidence interval (2.21–16.68), P<0.001). The multivariate logistic regression model demonstrated a substantial and significant increase in the odds of thoracic spine involvement when more than two cervical spine lesions were present, two lesions (OR 4.44, (0.91–21.60), P=0.06), three lesions (OR 19.76, (3.51–111.17), P=0.001), four or more lesions (OR 20.49, (1.97–213.23), P=0.012) and diffuse lesions (OR 71.94, (5.28–979.88), P=0.001), when adjusting for significant covariates including clinical symptoms, brain lesions, disease duration and treatment exposure.

Conclusions:
Thoracic spinal cord lesions appear to be predicated on the degree of cervical spine involvement in patients with MS, a risk that appears to be independent of brain findings or clinical features.

Story Source: The above story is based on materials provided by NATURE
Note: Materials may be edited for content and length

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