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Friday

 

Pediatric-onset multiple sclerosis disease progression in Kuwait: A retrospective analysis: STUDY

































Image source: OLSTARS

Abstract

Background:
Pediatric and adults patients share basic aspects of multiple sclerosis, however, pediatric patients may have distinctive clinical features and disease course.

Objective
To compare the demographic and clinical characteristics between patients of pediatric-onset and adult-onset MS.

Methods:
Utilizing the national MS registry, MS patients who had their disease onset at age ≤17 years (pediatric-onset MS) or > 17 years (adult-adult MS) were identified. Several demographics and clinical characteristics were analyzed. Disability measures and time to reach secondary progressive MS were compared between the two cohorts using Chi-square and student t tests.

Results:
A total of 984 records of MS patients were assessed; of whom 111 (11.3%) had disease onset at age ≤17 years. The female to male ratio did not differ between the two groups (p = 0.19). The mean age at onset of pediatric-onset and adult-onset MS were 14.9 and 27.68 years respectively. Pediatric-onset MS patients were more likely to have brainstem/ cerebellum (p <0.03) and multifocal (p <0.01) presentations at onset. The mean number of relapses did not differ between the two cohorts (3.4 ±2.1 versus 3.05 ±2.2; p = 0.14). The mean EDSS score at last visit was lower in pediatric-onset cohort compared to adult-onset cohort (2.38 ±1.72 versus 3.02 ±2.18; p = 0.003). The time to develop secondary progressive MS was longer in the pediatric-onset cohort (14.6± 4.6 years versus 11.0 ±5.3 years; p <0. 0.04).

Conclusions:
Pediatric-onset MS patients were more likely to have brainstem / cerebellar and multifocal symptoms at onset. Although, the number of relapses was comparable to adult-onset cohort, MS patients with pediatric-onset had lower EDSS scores and longer time to reach secondary progressive course at last follow-up visits.

Story Source: The above story is based on materials provided by PEDIATRICNEUROLOGY
Note: Materials may be edited for content and length

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