FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Wednesday

 

Gene Regulating Treatment Response in Multiple Sclerosis Identified





































Image source:CHONGSOONKIM

A gene for multiple sclerosis (MS) activity has been identified, according to research published in the Annals of Neurology.

Researchers from Brigham and Women’s Hospital examined MS patient disease activity and its link to interferon-beta treatment in order to identify biomarkers for further clinical development and to investigate the pathophysiology of MS disease activity. The researchers wrote that some MS patients experience disease activity despite treatments. Moreover, the authors said, early identification of the most effective drug is important to impacting the long-term outcome for each individual MS patient and improving the personalized approach for treatment.

“This study highlights the fact that genetic variation has a role in the course of a patient’s disease in MS, but that this role is modest and will require much larger studies to be understood in detail,” study author Philip De Jager, MD, PhD, director of the Program in Translational NeuroPsychiatric Genomics at the Ann Romney Center for Neurologic Diseases at BWH explained in a press release. “We need to expand this type of international, collaborative science.”

After screening the genome of MS patients being treated with interferon-beta at the affiliated hospitals of each of the authors (which included Brigham and Women’s, as well as hospitals in Italy and France), the researchers found that the gene that was the most highly indicative of whether or not a patient would respond to treatment was SLC9A9.

“Further work is now needed to validate our results in other collections of patients, particularly patients treated with other MS medications, to evaluate whether the effect of the genetic variant is limited to interferon-beta treatment or is relevant to other clinical MS treatments,” Filippo Martinelli Boneschi, MD, PhD, of San Raffaele Scientific Institute, continued in the statement.

The researchers added that although the role is confirmed in MS, it is weak. The laboratory work in the study demonstrated that the loss of the SLC9A9 gene contributes to immune cells becoming much more likely to initiate damaging immune reactions.

“Manipulations of this gene in mice and in human cells will lead us to better understand mechanisms that are involved in the autoimmune response that causes MS,” added Wassim Elyaman, PhD, an investigator in the Program in Translational NeuroPsychiatric Genomics at the Ann Romney Center for Neurologic Diseases at BWH. - See more at: http://www.hcplive.com/medical-news/gene-regulating-treatment-response-in-multiple-sclerosis-identified-#sthash.ljh0fEhH.dpuf

Story Source: The above story is based on materials provided by HCPLIVE
Note: Materials may be edited for content and length


Go to Newer News Go to Older News