FRONT PAGE AMPYRA AUBAGIO AVONEX BETASERON COPAXONE EXTAVIA
Stan's Angels MS News Channel on YouTube GILENYA NOVANTRONE REBIF RITUXAN TECFIDERA TYSABRI
 Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
CLICK ON THE RED BUTTON BELOW
You'll get FREE Breaking News Alerts on new MS treatments as they are approved
MS NEWS ARCHIVES: by week

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
and
Medical Director-Rocky Mountain MS Center


Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an M.D....my Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore


This page is powered by Blogger. Isn't yours?

Monday

 

Specific brain chemical may play role in promoting chronic pain





































Image source: SUSAN-DEBORAH

A chemical in the brain typically associated with cognition, movement and reward-motivation behavior -- among others -- may also play a role in promoting chronic pain, according to new research at The University of Texas at Dallas.

The chemical, dopamine, sets the stage for many important brain functions, but the mechanisms that cause it to contribute to chronic pain are less well understood.

In a recent paper published in The Journal of Neuroscience, UT Dallas researchers followed the sequence of pain impulses traveling from the brain to the spinal cord in mice. They found that by removing a collection of neurons called A11 that contain dopamine, chronic pain was selectively diminished.

"These findings demonstrate a novel role for how dopamine contributes to maintaining chronic pain states," said Dr. Ted Price, associate professor in the School of Behavioral and Brain Sciences at UT Dallas. "This may open up new opportunities to target medicines that could reverse chronic pain." Pain signals travel like electricity from an injury to the spinal cord where they pass on electrical or chemical pain signals to other cells. Those pain signals then travel upward and relay that information to neurons in the brain where they can be distributed throughout. There is no single pain center in the brain, but there is substantial evidence that chronic pain changes how these pain centers are activated.

In people with chronic pain, neurons continue to send pain signals to the brain, even in the absence of injury, but the causes of this are not known. A potential explanation comes from A11. These neurons didn't affect acute pain, but they did have a profound effect on chronic pain, researchers found. By targeting these neurons in mice with chronic pain, the researchers permanently reversed a chronic pain state.

Price said that previous studies have examined the role of other neurotransmitters in chronic pain including norepinephrine and serotonin. "By process of elimination, we decided to look more closely at dopamine. We used a toxin that affected A11 neurons, and that's when we found that acute pain signals were still normal, but chronic pain was absent," he said.

In 2011, the Institute of Medicine estimated that more than 100 million Americans suffer from chronic pain, a condition that costs more than $600 billion each year in medical care and lost productivity.

Story Source: The above story is based on materials provided by NEWSMEDICAL
Note: Materials may be edited for content and length

Labels:



Go to Newer News Go to Older News