Daily News for Neuros, Nurses & Savvy MSers: 208,152 Viewers, 8,368 Stories & Studies
Click Here For My Videos, Advice, Tips, Studies and Trials.
Timothy L. Vollmer, MD
Department of Neurology
University of Colorado Health Sciences Center Professor

Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
Click here to read my columns
Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
You'll get FREE Breaking News Alerts on new MS treatments as they are approved

HERE'S A FEW OF OUR 6000+ Facebook & MySpace FRIENDS
Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
Medical Director-Rocky Mountain MS Center

Click to view 1280 MS Walk photos!

"MS Can Not
Rob You of Joy"
"I'm an Mom has MS and we have a message for everyone."
- Jennifer Hartmark-Hill MD
Beverly Dean

"I've had MS for 2 years...this is the most important advice you'll ever hear."
"This is how I give myself a painless injection."
Heather Johnson

"A helpful tip for newly diagnosed MS patients."
"Important advice on choosing MS medication "
Joyce Moore

This page is powered by Blogger. Isn't yours?



I-Carnitine not effective for depression and chronic fatigue in MS and Neuromyelitis Optica

A new study confirmed that depression and chronic fatigue often occur in multiple sclerosis (MS); and in a related condition known as neuromyelitis optica (NMO). NMO is similar to MS because myelin–the fatty substance that insulates nerve cells and helps them to communicate–is also lost. In NMO the myelin deteriorates mostly in the optic nerve, which can lead to blindness, and in the spinal cord. In MS myelin can be lost throughout the nervous system.

Anyone who has MS knows that depression and chronic fatigue commonly go along with the disease. Although having a chronic medical condition can certainly worsen mood, the loss of myelin in the nervous system may also contribute to depression and loss of energy. Some scientists believe that low carnitine levels in the blood could cause depression and fatigue, possibly even due to the use of medications. Carnitine helps to transport essential nutrients to muscle cells, so lower levels could have a direct effect of energy. One way to increase carnitne could be by giving people the oral supplement acetyl levocarnitine (l-carnitine).

In their study, titled “Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica“, published in the Journal of Neuroimmunology, researchers decided to study depression, fatigue and the use of l-carnitine in seventy-five patients with MS and 39 patients with NMO at Tohoku University Hospital in Japan. Tetsuya Akaishi of the Department of Neurology, Tohoku University School of Medicine, Sendai, Japan, led the study. The scientists found that participants more often had severe and not mild levels of depression, in a total of 47 MS patients (62.7%) and 29 NMO patients (74.4%).

The team also studied eleven patients with low carnitine levels (six MS and five NMO patients), who agreed to take l-carnitine at 1800 mg/day for a month. However, the low carnitine levels were not associated with increased depression and fatigue and taking l-carnitine for a month did not improve depression or fatigue in these 11 individuals.

In their report, the researchers concluded ” Carnitine is occasionally low in the sera of MS and NMO, but does not seem to play a major role in depression and fatigue in these diseases. Measurement of the serum carnitine levels and administration of oral l-carnitine seem not to be beneficial.”

The research underscores the importance of assessing emotional symptoms and energy levels in people with diseases associated with myelin loss, including MS and NMO. This is the first study to identify that these problems are also common in people with NMO. Unfortunately, l-carnitine supplements do not seem to be a good treatment for depression and fatigue in the two diseases. Future studies will hopefully focus on more effective treatments.

Story Source: The above story is based on materials provided by MULTIPLESCLEROSISNEWSTODAY
Note: Materials may be edited for content and length

Labels: ,

Go to Newer News Go to Older News