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Tuesday

 

Hypovitaminosis D and the Risk of Multiple Sclerosis in Blacks and Hispanics: STUDY





































Vitamin D Sources

Abstract

Objective:
To determine whether hypovitaminosis D a risk factor for MS in blacks and Hispanics. 

Background:
Hypovitaminosis D is a risk factor for multiple sclerosis (MS) and it’s precursor, clinically isolated syndrome (CIS), in whites but whether this is true for darker skinned individuals who typically have lower serum 25-hydroxyvitamin D (25(OH)D) levels has not been studied. 

Design/Methods:
Reported is the interim analysis of a case-control study of newly diagnosed MS/CIS cases and controls matched on sex, age, race/ethnicity and geography from themembership of Kaiser Permanente Southern California, 2011-present; MS Sunshine study. Data are collected via structured in-person interview, complete electronic health record and blood draw; and analyzed using conditionallogistic regression. 

Results:
Included are 89 blacks and 104 Hispanics with newly diagnosed MS/CIS and their 93 and 107 matched controls. Mononucleosis and family history of MS are less common among Hispanics than blacks (3.2[percnt] vs. 6.0[percnt] mononucleosis; 5.2[percnt] vs 17.0[percnt] family history, respectively). Both factors are associated with a higher risk of MS in blacks and Hispanics, although statistical significant is reached only in blacks. Deseasonalized serum 25(OH)D levels are similar among black cases (mean 22.6, range=4.0-66.0ng/mL) and controls (19.6;0.1-46.9; p=0.25) and Hispanic cases (23.3;6.0-70.0) and controls (22.9;4.6-47.0;p=0.725). A 4ng/mL (10nmol/L) increase in serum 25(OH)D is not associated with a decreased risk in Hispanics (adjusted OR=1.05 95[percnt]CI=0.92-1.20; p=0.49) and in blacks is associated an slight increase in MS risk (adjusted OR=1.19 95[percnt]CI=1.03-1.38;p=0.02) after adjusting for history of mononucleosis, smoking and family history of MS.

Conclusions:
Hypovitaminosis D does not appear to be a risk factor for MS in Hispanics and blacks. These findings highlight the complexity of unraveling the relationship between vitamin D and MS and the importance of including multiple racial/ethnic groups in MS susceptibility studies. Study Supported by: NINDS-NIH-R01NS075308

Story Source: The above story is based on materials provided by NEUROLOGY
Note: Materials may be edited for content and length

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