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Cognitive Impairment is Associated with Behavioral Problems in Pediatric Multiple Sclerosis: STUDY

































Image source: superpharmacy.com.au

Abstract

Objective:
To characterize the behavioral problems in pediatric MS and their link to cognitive impairment.

Background:
Pediatric MS patients represent 2-5[percnt] of all MS cases, with one-third having cognitive impairment. In adults, behavioral changes have been associated with intrinsic changes within the brain as well as the psychosocial burden of illness. DESIGN/METHODS: Participants with pediatric-onset MS were consecutively evaluated at the Lourie Center for Pediatric MS and administered the Behavioral Assessment System for Children, second edition (BASC-2), self- and parent-report forms and neuropsychological evaluation. The BASC-2 includes clinical and adaptive functioning scales, with impairment determined by scores falling greater than two standard deviations or below norms. Cognitive impairment was defined as one-third of scores falling one standard deviation or more below norms.

Results:
There were 145 patients, with a mean age of 14.7 ± 2.7 years (range 5 to 18) and 57[percnt] female. Mean disease duration was 1.5 ± 2.3 years; the median EDSS was 1.0 (range 0 to 6.5). Behavioral concerns were frequent: 68[percnt] of children and 81[percnt] of parents rated at least one scale in the clinically significant range. However, no consistent pattern emerged with mean BASC-2 scores falling within the typical range for the sample (mean t scores between 45 and 55). For both self-/parent-reports, the most frequently reported concerns were attention problems (28[percnt]/ 29[percnt]) and somatization (35[percnt]/ 27[percnt]). Participants with cognitive impairment reported significantly higher rates of problems in school, mood disturbances and interpersonal problems, and were rated by parents as having significantly lower adaptive functioning.

Conclusions:
Behavioral concerns are frequent but highly variable in pediatric MS. Cognitive impairment is associated with a greater risk of reported behavioral problems affecting school, mood, and interpersonal functioning. Study Supported by: The Lourie Foundation, Inc., National Multiple Sclerosis Society, and the Slomo and Cindy Silvian Foundation

Story Source: The above story is based on materials provided by NEUROLOGY
Note: Materials may be edited for content and length

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