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Timothy L. Vollmer, MD
Department of Neurology
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Co-Director of the RMMSC at Anschutz Medical Center

Medical Director-Rocky Mountain MS Center
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Brian R. Apatoff, MD, PhD
Multiple Sclerosis Institute
Center for Neurological Disorders

Associate Professor Neurology and Neuroscience,

Weill Medical College of Cornell University

Clinical Attending in Neurology,
New York-Presbyterian Hospital
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Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
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Friday

 

15 STUDIES IN FRIDAY'S NEWS

PLUS: 1380 new Studies we posted from 11/1 to Thursday 1/30 Start at the Bottom! 


Magnetic susceptibility of MS lesions increased rapidly as it changed from enhanced to nonenhanced, it attained a high susceptibility value relative to NAWM during its initial few years (approximately 4 years), and it gradually dissipated back to susceptibility similar to that of NAWM as it aged, which may provide new insight into pathophysiologic features of MS lesions.

In a cohort with different stages of MS, higher EA attenuated the negative effects of white matter lesion burden and third ventricle width (suggestive of thalamic atrophy) on cognitive performance. Actively enhancing cognitive reserve might thus be a means to reduce or prevent cognitive problems in MS in parallel to disease modifying drugs.

Grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers (global brain atrophy and T2 hyperintense lesions). Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect.

results confirm the important role of the immune system and specifically B cells in MS and suggest that MS risk variants exert a gene regulatory role. Previous studies assessing MS risk variants in T cells may be missing important effects in B cells. Similar analyses in other immunological cell types relevant to MS and functional studies are necessary to fully elucidate how genes contribute to MS pathogenesis.

Fatigue management program outcomes for people with MS are moderated by age, gender, and impairment.
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Imaging Technique Shows Brain Anatomy Change in Women with Multiple Sclerosis, Depression
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Lack of awareness adds to multiple sclerosis pain in India
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MS Therapy Tysabri (Natalizumab) Being Tested In New Clinical Trial

 

Thursday

 

New toxin found in dirt and certain strains of food bacteria may trigger MS... Something so simple. Love it!




This sounds so interesting; imagine something so simple as dirt or bacteria in food. 



Epsilon toxin may be a trigger for MS

MS is thought to result when genetically susceptible individuals are exposed to one or more environmental triggers. But while we have not yet firmly identified the triggers, there is increasing evidence, like this latest research, that a toxin called epsilon produced by certain strains of food bacteria is one of them, as Dr. Linden explains:



Jeannine Everett, MSer &Columnist, MSnewsChannel.com

 

15 STUDIES IN THURSDAY'S NEWS

PLUS: 1365 new Studies we posted from 11/1 to Wednesday 1/29 Start at the Bottom! 


Employment status was an explanatory variable for physical health and mental health in the younger patients. EDSS played a significant role in physical health for all patients. A vocational rehabilitation program could prevent eventual nonemployment and improve health outcomes in older MS people.

Simultaneous characterizations of changes in tonic and, phasic reflexes and nonreflex changes in joint elastic stiffness and, viscosity in neurological disorders may help us gain insight into, mechanisms underlying spasticity and develop impairment-specific, treatment.

Using an active prospective surveillance system and the McDonald criteria for first MS diagnosis the age-related incidence of pediatric MS in Germany was uncovered and is more common than in previous estimates. Thorough application of McDonald criteria and inclusion of spinal MRI data allowed for early diagnosis in almost 90% of cases.

A high prevalence of urinary symptoms and urodynamic dysfunctions in patients with CISs and an association of urinary symptoms with quality of life measures were found. These results highlight the importance of identifying and optimally treating urinary symptoms also at the very early stages of MS.

The inflammatory mechanisms associated with lesion formation in MS are to a large extent reflected in experimental models of inflammatory demyelination, such as autoimmune encephalomyelitis. This is not the case for the amplification mechanisms of oxidative injury, which mainly operate in the progressive stage of the disease. GLIA 2014.
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Medical THC. There are literally HUNDREDS of ailments marijuana helps including Multiple Sclerosis, arthritis, and the nausea from chemotherapy for cancer patients. This list goes on.


 

New research shows that Multiple Sclerosis may steal as much as six years from patients' lifespans.

New research shows that Multiple Sclerosis may steal as much as six years from patients' lifespans.
Read more »

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Put Sativex photo

Multiple Sclerosis and Sativex Spray Marijuana, An Important Update
Read more »

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Teva Pharmaceutical Industries Ltd.

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) announced today that the U.S. Food and Drug Administration (FDA) has approved the Company's supplemental new drug application (sNDA) for three-times-a-week COPAXONE
Read more »

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Patients with multiple sclerosis (MS) may have an increased risk of developing cancer, particularly breast cancer
Read more »

 
Epsilon toxin may be a trigger for MS: Evidence that a toxin produced by a common food bug may trigger multiple sclerosis
Read more »

 

Biogen Idec and UCB Enter Agreements to Commercialize Multiple Sclerosis and Hemophilia Therapies in Asia

Wednesday

 

15 STUDIES IN WEDNESDAY'S NEWS

 
Based on current evidence there is no longer doubt that B cells are relevant to the etiology and pathogenesis of MS. Elucidating the role of B cells in MS will be a fruitful strategy for disease prevention and treatment. 

Read more »

 
An acne bacteria-derived drug for the treatment of Secondary Progressive Multiple Sclerosis (SPMS).
Read more »

 
Trevor Bayne
Trevor Bayne doesn’t mind telling his story about racing with multiple sclerosis, but he’s not interested in having that define him.

Read more »

 
The non-profit Myelin Repair Foundation (MRF) may have identified a proven drug for hypertension that could be used to stimulate repair and protect the brain in MS patients.
Read more »

 
Multiple sclerosis (MS) may be triggered by a toxin produced by common bacteria found in food, according to a new study.  

Read more »

 

Rep. Charisse Millett
Representative, Charisse Millett, says doctors have discovered a brain lesion that could be a sign of multiple sclerosis.   

Read more »

 
Similarity in Genetic pleiotropy Show a Lowered Risk of Schizophrenia for MSers
Read more »

 
Medical Marijuana May Be an Option in Guam Soon: It's up to the voters
Read more »

Tuesday

 

15 STUDIES IN TUESDAY'S NEWS

 
There are many MSers in the United States who are upset with the FDA for not approving of the drug Lemtrada (Alemtuzumab), to the point where a petition was made to fight the ruling.
Read more »

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A generic high blood pressure drug could unlock a new treatment window for multiple sclerosis patients
Read more »

 
MSPrecise®, its proprietary next-generation sequencing (NGS) assay for the identification of patients with multiple sclerosis (MS) at first clinical presentation. The prospective study met its primary endpoint by demonstrating the ability of MSPrecise to diagnose patients with MS.
Read more »

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New Dug, Siponimod in Phase 3 Trial For Secondary Progressive Multiple Sclerosis
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Dr. Alberto Ascherio, a professor of epidemiology and nutrition at the Harvard School of Public Health and lead author, said that the sunshine vitamin can prove beneficial to early stage MS patients.

Dr. Alberto Ascherio
Dr. Alberto Ascherio, a professor of epidemiology and nutrition at the Harvard School of Public Health and lead author, said that the sunshine vitamin can prove beneficial to early stage MS patients.
Read more »

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Micheal Evans, MSer
Advocates of alemtuzumab had their hopes dashed in mid-December, when the FDA ruled that clinical trials for the drug were not conclusive enough, postponing its approval until further trials are completed.
Read more »

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Monday

 

15 STUDIES IN MONDAY'S NEWS

 

Massachusetts officials are nearing decisions on the licensing of medical marijuana dispensaries in the state. The Department of Public Health hopes to award as many as 35 licenses by the end of the month, choosing from among 100 groups that submitted final applications in November.

Massachusetts officials are nearing decisions on the licensing of medical marijuana dispensaries in the state. The Department of Public Health hopes to award as many as 35 licenses by the end of the month, choosing from among 100 groups that submitted final applications in November.
Read more »

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MSer and mother of 5, Melissa Saleski-Shingara, an RN files suit, claims she was fired while on maternity leave
Read more »

 

Copaxone (Glatiramer Acetate) had sales of almost $4 billion. A U.S. patent protecting the drug until 2015 was invalidated in July by a U.S. Court of Appeals, opening the way for cheaper generic competitors as soon as May.

Copaxone (Glatiramer Acetate) had sales of almost $4 billion. A U.S. patent protecting the drug until 2015 was invalidated in July by a U.S. Court of Appeals, opening the way for cheaper generic competitors as soon as May.
Read more »

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Efforts to legalize marijuana in New York have gained momentum since Gov. Andrew Cuomo announced a proposal earlier this month to make pot available on a limited basis to people who are seriously ill.

Efforts to legalize marijuana in New York have gained momentum since Gov. Andrew Cuomo announced a proposal earlier this month to make pot available on a limited basis to people who are seriously ill.
Read more »

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Multiple Sclerosis Annual Conference Presents the Latest on Diagnosis, Patient Care & Research
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Aubagio (Teriflunomide) has been approved by the National Institute for Health and Care Excellence (NICE) with the help of Letchworth GC charity
Read more »

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Investors in Israel's Teva Pharmaceutical Industries largely shrugged off a negative opinion from the European Medicines Agency (EMA) on multiple sclerosis (MS) drug laquinimod in the belief that it will be reformulated.

Investors in Israel's Teva Pharmaceutical Industries largely shrugged off a negative opinion from the European Medicines Agency (EMA) on multiple sclerosis (MS) drug laquinimod in the belief that it will be reformulated.
Read more »

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Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal
Read more »

Sunday

 

15 STUDIES IN SUNDAY'S NEWS

PLUS: 1320 new Studies we posted from 11/1 to Saturday 1/25 Start at the Bottom!
Read more »

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One pharmaceutical company could become the safest and most trusted of all cannabis dealers. Sativex is not available for use in the US market, it is available in 24 countries around the world, and GW is seeking to expand its use into the market.

One pharmaceutical company could become the safest and most trusted of all cannabis dealers.  Sativex is not available for use in the US market, it is available in 24 countries around the world, and GW is seeking to expand its use into the market.
Read more »

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Vitamin D -- the MS Magic Bullet?  Feedback takes a second look at a reported correlation between vitamin D and slower disease progression in multiple sclerosis patients.
Read more »

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Cabinet has approved a supplementary budget of €1.8 million to be spent on drugs for Thalassaemia and multiple sclerosis patients whose lives were put at risk because they had not received medication in due time.
Read more »

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Fluoxetine might theoretically reduce axonal degeneration in MS: Currently available disease-modifying treatments acting by modifying the immune response are ineffective in progressive multiple sclerosis (MS), which is caused by a widespread axonal degeneration

Read more »

 

Generic competition will soon eat away sales of its workhorse multiple sclerosis drug Copaxone (Glatiramer Acetate).

Generic competition will soon eat away sales of its workhorse multiple sclerosis drug Copaxone (Glatiramer Acetate)
Read more »

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One rapidly emerging area is the role of brain volume loss in multiple sclerosis (MS), an autoimmune disease that affects 2.5 million people around the world
Read more »

 
If you're baffled by how many of your patients, particularly those with chronic conditions, don't take their medications as prescribed if at all, you're not alone. Doctors from coast to coast feel frustrated by the same thing.
Read more »

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Saturday

 

15 STUDIES IN SATURDAY'S NEWS

 

A soft, wearable device that mimics the muscles, tendons and ligaments of the lower leg could aid in the rehabilitation of patients with ankle-foot disorders





 
The latest setback on the vitamin D theory is a major study. They found that vitamin D supplementation with or without calcium doesn’t seem to play a significant role in serious conditions.
Read more »

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Although a rare condition, multiple sclerosis (MS) appears to be more common among overweight and obese girls, to the point where extremely obese girls have nearly four times the risk of developing the neurological disease
Read more »

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Rituxan, an experimental pill could turn a lethal cancer into a chronic, but manageable disease like high blood pressure
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MS patients may in fact be at an 85% greater risk of developing cancer, particularly breast cancer than healthy individuals.
Read more »

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Teva Pharmaceutical Industries Ltd.  and Active Biotech announced today that both companies remain committed to the NERVENTRA® (laquinimod) clinical development program for multiple sclerosis
Read more »

 

Over the next five years, the global multiple sclerosis market is set to grow from $14.4 billion in 2012 to $18.3 billion in 2017.

 
While early mortality due to MS is relatively rare, the new data confirm that compared to the general population, MS patients in the US do experience a decrease in life expectancy
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Friday

 

MS News Channel Expert Neurologist: Brian R. Apatoff, MD, PhD: MULTIPLE SCLEROSIS AND PAIN


Brian R. Apatoff, MD, PhD

Have a question for Dr. Apatoff or Dr.Vollmer? 
Send it to our CEO: Stan@MSnewsChannel.com

MULTIPLE SCLEROSIS AND PAIN

Many patients will experience a variety of sensory symptoms in the course of their condition, often at diagnosis, and frequently with an unpleasant quality to their sensory complaints.  Thus, a patient may have sensory disturbance or paresthesias (numbness, tingling, "pins and needles") that can also take on an unpleasant quality (with a variety of deep aching, diffuse burning, shooting electrical, itching, stiffness, tight constricting elements).

The nature and location of these discomforting feelings, or sensory dysesthesia, are related to where the demyelination and damage is occurring in the sensory pain pathways, typically in the brainstem or spinal cord.  For example, many patients describe headache pain in the top or back of their head (vertex or occipital headache)......
Read more »

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15 STUDIES IN FRIDAY'S NEWS

 
Many cases of neurological illness may be caused and/or exacerbated by gluten consumption.   Patients with neurological illness of an unknown cause, 30 of 53 patients (57%) had antibodies against gluten in the blood.
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Bill was introduced in the Legislature to legalize medical marijuana to ease the pain of cancer victims, the nausea of AIDS sufferers, the muscle spasms of multiple sclerosis patients, and the like.

Bill was introduced in the Legislature to legalize medical marijuana to ease the pain of cancer victims, the nausea of AIDS sufferers, the muscle spasms of multiple sclerosis patients, and the like.
Read more »

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The National Institute for Health and Care Excellence (NICE) has issued its final guidance recommending the use of Genzyme's multiple sclerosis drug teriflunomide (Aubagio
Read more »

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Nonconventional MRI-based measures better assess the serial changes in newly forming lesions and improve our understanding of the relationship between the damaging and reparative mechanisms that occur in MS.
Read more »

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The risk of an MS patient's sibling developing the disease is seven times higher compared to the general population, while the risk for a child of an MS patient is five times higher, no increase in risk for grandchildren or nieces and nephews.
Read more »

 
FDA decision has generated such fury in the multiple sclerosis community, extending even to senior clinical trial investigators as well as patients over rejection of Lemtrada (Alemtuzumab)
Read more »

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Harvard School of Public Health (HSPH) in Boston studied patients with MS, finding that those with higher levels of vitamin D fared much better than those with lower levels.
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The landscape for MS treatments is expected to change during the forecast period, as several anticipated new drugs enter the market.

The landscape for MS treatments is expected to change during the forecast period, as several anticipated new drugs enter the market. The first orally administered disease-modifying therapy, fingolimod (Gilenya), which competes with Copaxone (Glatiramer Acetate).
Read more »

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Thursday

 

15 STUDIES IN THURSDAY'S NEWS

 

Study Shows 85% Increase in Cancer Risk For Multiple Sclerosis Patients.  MS patients in Taiwan may require more regular and earlier cancer screening
Read more »

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Teva Pharmaceutical Industries ($TEVA) is making one last desperate plea to the U.S. Supreme Court.

Teva Pharmaceutical Industries ($TEVA) is making one last desperate plea to the U.S. Supreme Court to appeal the U.S. Circuit Court's ruling shortened Copaxone's (Glatiramer Acetate) exclusive access to the market by 18 months
Read more »

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Meditation in patients with mild cognitive impairment (MCI) may slow progression of disease. People who received mindfulness-based stress reduction (MBSR) therapy for 8 weeks had a greater increase in functional connectivity between brain regions
Read more »

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Depression, the silent killer. Up to 50% of MSers will experience major depression in their lifetime; this is much higher than the general population or for people with other chronic disabling diseases
Read more »

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Drinking in May Accelerate Cognitive Decline.  Excessive alcohol consumption is known to have detrimental short- and long-term effects on the brain
Read more »

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One of the key omega-3 fatty acids is docosahexaenoic acid (DHA).Eating more fish could give you a bigger brain - and greater protection against diseases
Read more »

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Firing an electromagnetic pulse into the brain can stop the pain of migraine for days and has now been recommended National Institute for Health and Care Excellence
Read more »

Wednesday

 

15 STUDIES IN WEDNESDAY'S NEWS

 
Results show that cutaneous adverse events are common with long-term Disease Modifying Therapy (DMT) treatment, that cutaneous reactions mostly involve local injection-site reactions and lipoatrophy, and that cutaneous adverse events somewhat lowers dermatologic-specific health-related quality of life of MSers
Read more »

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Repeat triamcinolone application improves dysfunction of upper and lower extremities even when administered 5 times only and in series every other day.
Read more »

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The impairments on disability level, walking and quality of life (QOL) of MS patients were related to (OQL) declines and increased burden of their caregivers.
Read more »

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Supermom, Nancy Davis, says when doctors told her she had multiple sclerosis she was told to just go home and go to bed. Instead, this 33-year mother of three went out and fought.  Davis is gearing up for her 21st year of Race to EraseMS. 
Read more »

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MS lesion
Though researchers stress that early death due to MS alone is rare, those living in the United States with MS compared to the general population may experience a decreased life expectancy
Read more »

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Some people with MS notice that symptoms, particularly spasticity, become worse in cold weather. It is generally recommended that people with MS who are sensitive to temperature try to avoid extremes of either hot or cold
Read more »

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A new study shows an unexpected benefit of even short bursts of moderate activity. The study offers that five bursts of exercises, lasting three minutes with two-minutes rests in between, were all it took to improve the MSers' lives.
Read more »

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Tuesday

 

Dee Ryden, Columnist, MSnewsChannel.com


Dee Ryden, Columnist
MSnewsChannel.com
Meet Dee, our new columnist to the MSnewsChannel.
Read her story!! 

My name is Dee Ryden

 I've known about MS since 8 years old, it skips generations in my family all women, I happen to be the generation and the person it picked, so I fight and I write. I ask you to never give up! I write this not as medical advise, this is based on my years (37) of living with Multiple Sclerosis. Diagnosed as a young woman, with a great career. By all medical books, I should not have lived through the first exacerbation, it being so progressive, within 3 mos. paralyzed from the neck down. This is not what I want to write about, much has changed in the 30 + years of treatment. Slowly overtime with P.T. & O.T., I regained a life I could tolerate. Having the 2nd exacerbation, an over night one, just 5 weeks after losing my husband, an enormous time of stress, which I couldn't control. This is when the train wreck started and it wouldn't stop. I lost the entire left side of my body the 2nd time, how forgiving MS
Read more »

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