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Sunday

 

Researchers in Demark, at The University of Copenhagen found a new type of regulatory blood cell that can fight the hyperactivity of T-cells in MS

What they found was something no one has ever seen before. T-cells (T lymphocytes) are a type of a white blood cell that has been found to play a central role in bringing about and regulating the “pathophysiology” of MS.
CLICK TO READ ABSTRACT AT "NATURE MEDICINE"

Although some scientists believe MS is more a clinical entity, meaning it is something that breaks off from something else as opposed to being the problem to begin with, researchers at The University of Copenhagen have chosen to look at “the functional changes” of the disease by examining blood cells in mice.

Yawei Liu, associated professor of the studies, had this to say, “We knew that some unidentified blood cells were able to inhibit multiple sclerosis-like disease in mice and through gene analysis we found out, that these cells are a subset of our lymphocytes expressing the gene FoxA1. Importantly, when inserting FoxA1 into normal lymphocytes with gene therapy, we could change them to actively regulate inflammation and inhibit multiple sclerosis.”

The ‘FoxA1’ mentioned is a class of DNA-binding proteins and it was never known it was the meaning behind lymphocyte development and suppressive functions.

This is very good news considering they can now focus on testing whether the FoxA1-lymphocytes can affect the myelin and “brain degeneration in a model of progressive multiple sclerosis” in mice and, if it holds true to what they believe they have already seen, work at figuring out new therapies for those with progressive forms of MS.

As things stand right now, those with progressive forms of MS don’t have many therapy options and it hasn’t been up until recent years that researchers have spent much time on this type of the disease.
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