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Thursday

 

RISK OF MULTIPLE SCLEROSIS INCREASED WITH ADOLESCENT OBESITY AND HLA GENOTYPE

A number of factors are associated with an increased risk of developing adult-onset multiple sclerosis (MS), including modulated immune function, vitamin D insufficiency, the human leukocyte antigen (HLA) genotype, and interaction with the Epstein-Barr virus. Interestingly, some of these risk factors are also associated with being obese. Since obesity is also associated with low-grade chronic inflammation, it is projected that the risk of HLA-related activation of T-cells contributes to an autoimmune attack on the central nervous system, leading to MS.
Dr. Anna Karin Hedström from the Karolinska Institutet in Sweden, along with colleagues from other institutes including the University of California, Berkeley, to investigate the link between adolescent obesity and HLA genes in the development of multiple sclerosis; results were published in Neurology.
 

Two case-control studies were conducted: the Epidemiological Investigation of MS (EIMS) study included 1,510 incident cases of MS, and the Kaiser Permanente Medical Care Plan in Norther California (KPNC) study included 937 prevalent cases of MS. Each patient, along with matched controls, was genotyped for HLA-DRBI*15 and HLA-A*02, and body mass index (BMI) at the age of 20 years was self-reported. READ MORE



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