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Timothy L. Vollmer, MD
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Multiple Sclerosis Institute
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Weill Medical College of Cornell University

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Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
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Sunday

 

Autologous haematopoietic stem cell transplantation is a very effective treatment of inflammatory active MS and can be performed with a high degree of safety at experienced centers

STUDY: Autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: the Swedish experience. RESULTS: At 5 years, relapse-free survival was 87%; MRI event-free survival 85%; expanded disability status
scale (EDSS) score progression-free survival 77%; and disease-free survival (no relapses, no new MRI lesions and no EDSS progression) 68%. Presence of gadolinium-enhancing lesions prior to HSCT was associated with a favourable outcome (disease-free survival 79% vs 46%, p=0.028). There was no mortality. The most common long-term side effects were herpes zoster reactivation (15%) and thyroid disease (8.4%). CONCLUSIONS: HSCT is a very effective treatment of inflammatory active MS and can be performed with a high degree of safety at experienced centres. http://www.ncbi.nlm.nih.gov/pubmed/24554104?dopt=Abstract


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