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Timothy L. Vollmer, MD
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Multiple Sclerosis Institute
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Department of Neurology
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Friday

 

High-Dose Flu Vax Better for Frail Elderly

MED PAGE TODAY
Among the frail elderly in long-term care, a high-dose influenza vaccine improved antibody responses compared with standard vaccines, a researcher said.

In a randomized, single-blind trial over two flu seasons, the higher dose gave superior responses to four out of five strains contained in the vaccines, according to Richard Zimmerman, MD, of the University of Pittsburgh.


For the fifth strain -- the 2009 pandemic H1N1 flu -- the response was non-inferior to the standard vaccine in the second year of the study, possibly because some participants had already been vaccinated against it, Zimmerman said at the IDWeek meeting here

The high-dose vaccine was approved in 2009 for people 65 and older, Zimmerman noted, but it was tested in healthy people, with an average age of 73, living in the community.
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