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Timothy L. Vollmer, MD
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Friday

 

BREAKING NEWS: AAN: Monoclonal Antibodies Shine in Relapsing-Remitting MS but Not All to Same Degree - in Meeting Coverage, AAN from MedPage Today



American Academy of Neurology Meeting: Monoclonal Antibodies Shine in Relapsing-Remitting MS but Not All to Same Degree 

Three monoclonal antibodies in development for relapsing-remitting multiple sclerosis show promise, but alemtuzumab (Campath) appears to be leading the pack, researchers reported here. Once-yearly alemtuzumab reduced relapse risk by 74% and risk of accumulation of disability by 71% compared with standard interferon (both P<0.0001), reported Alasdair Coles, Ph.D., of the University of Cambridge in England, and colleagues, here at the American Academy of Neurology meeting. The benefit continued for two years after the last dose in a subset of patients, according to three-year data from a randomized trial. Other monoclonal antibodies, including daclizumab (Zenapax) and rituximab (Rituxan, MabThera), also looked promising in studies presented here. However, the improvements with alemtuzumab were "probably greater than anything else that's currently on the market or any of the drugs that are being looked at," said Lily Jung, M.D., of the Swedish Neuroscience Institute in Seattle, who commented on the studies. The specific targets of the monoclonal antibodies may account for the differences, Dr. Coles said. Daclizumab is targeted against CD25 on T cells and rituximab is targeted to B cells, but alemtuzumab impacts both types of lymphocytes. "We think one reason why our efficacy is so much better than other more selective monoclonal antibodies is because it has this sort of broad range of action," he said. The phase II CAMMS223 trial included 334 patients with early, active relapsing-remitting disease. Participants were randomized to 44 mcg beta interferon-1a (Rebif) injections three times a week or to once-a-year treatment with either 12 or 24 mg intravenous alemtuzumab delivered every day for five days at baseline and then daily for three days at months 12 and 24. Cumulative relapse rates continued to diverge in favor of alemtuzumab through three years of follow-up for a 74% risk reduction (annualized relapse rate 0.10 versus 0.36, P<0.0001). The load of T2 lesions seen on MRI were reduced to a greater degree with the monoclonal antibody (-16.45 versus -13.3%, P=0.005) and T1 cerebral volume fell less with alemtuzumab as well (-0.5% versus -1.8%, P=0.049). The continued effects were notable because only 46 patients in the alemtuzumab groups received therapy at the 24-month stage. For most participants, dosing was suspended when one patient died of immune thrombocytopenic purpura (ITP) on treatment. ITP was seen in six of 216 patients on alemtuzumab and one of 107 patients on interferon, but all other cases were identified early and treated successfully if needed. Thyroid events were also elevated with the drug but could be monitored and easily treated, Dr. Coles said. Dr. Jung agreed that neither of the more serious adverse events were a deal breaker for the drug, because both can be monitored unlike the progressive multifocal leukoencephalopathy issues seen with natalizumab (Tysabri). Rather, she was impressed by the reversion of disability in the alemtuzumab group. Mean scores on the Expanded Disability Status Scale at three years decreased 0.39 points with the monoclonal antibody compared with an increase of 0.38 for the interferon group (P<0.0001). "We believe this to be unprecedented," Dr. Coles said. Long dosing intervals may be another advantage. Although patients will likely need two cycles of therapy, they may be able to go for three to five years thereafter without treatment, Dr. Coles said. "I think it's a significantly easier treatment for patients," Dr. Coles said. "That's potentially even more acceptable than a daily tablet because you can forget about your illness." For daclizumab, though, treatment will likely have to be given long term because of a rapid loss of efficacy after discontinuation, said Michael D. Kaufman, M.D., of the Carolinas Medical Center in Charlotte, N.C., and colleagues. Their phase II CHOICE study included 230 relapsing-remitting MS patients randomized to 20 weeks of treatment with beta interferon plus placebo, daclizumab 1 mg/kg, or daclizumab 2 mg/kg. For the previously reported primary endpoint findings, new or enlarged gadolinium-enhancing lesions were 25% fewer at 24 weeks with lower dose daclizumab and 72% fewer with the higher dose compared with placebo (3.6 and 1.3 versus 4.8, P=0.514 and P=0.004, respectively). However, these benefits faded within 10 to 20 weeks after stopping treatment. During the 48-week observation phase of the study, the number of new enhancing lesions seen on MRI at week 34 was not significantly different between treatments although there were 56% more with 1 mg/kg and 23% fewer with 2 mg/kg daclizumab compared with placebo (3.56 and 1.77 versus 2.29, P=0.22 and P=0.49, respectively). In another small study, rituximab reduced the frequency of inflammatory brain lesions and relapses through 72 weeks, reported Amit Bar-Or, M.D., of McGill University in Montreal, and colleagues. Their phase I, open-label trial included 26 patients with relapsing-remitting MS given in two courses of two 1,000-mg rituximab infusions six months apart. Patients had rapid, sustained B cell depletion through 48 weeks followed by partial recovery by week 72. Reductions in gadolinium-enhancing lesions and the number and volume of new T2 lesions were rapid, starting at week four, and sustained through week 72. Relapses were also reduced over 72 weeks compared with the year prior to study treatment. Although how these monoclonal antibodies will play out for clinical use remains to be seen, these findings suggest that alemtuzumab would be used as the initial therapy for newly diagnosed patients with the other agents serving as options for patients with a poor response to other therapies, Dr. Jung said. [Note that these studies were published as abstracts and presented orally at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.]

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Wednesday

 

Genentech, Biogen's Rituxan Medicine Fails to Slow MS (Update3)

 Genentech Inc. and Biogen Idec Inc.'s cancer drug Rituxan failed to slow the disabling effects of the most difficult-to-treat form of multiple sclerosis in a large clinical trial.

Rituxan didn't reach its main goal of slowing disability for people with primary progressive multiple sclerosis after almost two years of treatment, compared with a placebo, the companies said in a statement. If the trial had succeeded, it would have made Rituxan the first drug to work against the primary progressive form of MS, or PPMS.

Rituxan, a blood-cancer drug that's also approved for rheumatoid arthritis, generated $2.29 billion in U.S. sales in 2007. It is designed to work by killing inflammatory B cells, a different approach than approved MS drugs. About 400,000 people in the U.S. have MS, and one in 10 have the primary progressive form that gradually damages nerve fibers over time without remissions, according to the National MS Society.

``While the primary results are not what we had hoped, we continue to believe in the potential of B cell therapy for patients living with MS,'' said Michael Panzara, Biogen's vice president and chief medical officer of its neurology strategic business unit.

Genentech, majority-owned by Switzerland's Roche Holding AG, fell 63 cents, or less than 1 percent, to $74.06 at 4 p.m. on the New York Stock Exchange. Cambridge, Massachusetts-based Biogen, a co-promoter of the drug, rose $1.21, or 2 percent to $64.93 on the Nasdaq Stock Market.

Revenue Opportunity

``This would have presented a revenue opportunity of more than 500 million Swiss francs for Roche but was not included in our model or consensus estimates,'' Deutsche Bank analysts including Michael Leuchten said in a note to investors today. ``PPMS is a tough part of MS to treat and nothing has worked in this setting so far.''

Multiple sclerosis is diagnosed when the body's immune system goes awry and begins attacking the fatty insulating tissue around nerve fibers, called myelin, according to the National MS Society.

The Rituxan trial, called Olympus, followed 439 patients for two years after they took an infusion of Rituxan or a placebo. Patients took a repeat course of Rituxan every six months, said Craig Smith, neurology lead clinical scientist in the immunology department at Genentech, in a telephone interview before the announcement.

Side Effects

Patients were monitored for the status of their disability, to see, for example, whether they were losing their ability to walk, see clearly, or maintain strength in their arms, Smith said. A secondary goal of the study looked at whether the drug reduced brain lesions.

More patients had serious side effects on Rituxan than on placebo, Genentech and Biogen said. The rate of serious side effects was about 16.4 percent in the Rituxan group, compared with 13.6 percent on placebo. About 4.5 percent of Rituxan patients had serious infections, compared with 1 percent on placebo. There was some evidence that the drug was working biologically, although the companies didn't specify how much in the statement.

Genentech and Biogen plan to continue analyzing the results and submit them at a future medical meeting, the companies said.

Double Vision

People in the trial were about 48 years old on average, and had been diagnosed with primary progressive MS four to 10 years before enrolling in the study, Smith said. They entered the study with an average disability score of 4 on a scale of 1 to 10, meaning they lacked some coordination, or had some double vision or weakness, although were still able to walk without assistance, he said.

Previously, Rituxan was studied for patients with the most common form of MS, the relapsing, remitting form. That study, called Hermes, found that one in five patients on Rituxan relapsed, while twice as many on placebo had a recurrence in a 48-week clinical trial, according to research published in February in the New England Journal of Medicine.

Existing drugs, including Biogen's Avonex, Bayer AG's Betaseron, Merck KGaA's Rebif and Teva Pharmaceutical Industries Ltd.'s Copaxone, work differently than Rituxan by blunting the attack of immune system T cells. None of the drugs have shown a benefit for patients with the primary progressive form of the disease, Smith said.

Next Steps

The market for MS drugs exceeded $5.5 billion in 2006 and is expected to double by 2013, according to market-research firm Frost & Sullivan in New York. Rituxan costs $20,514 a year for two infusions for patients with rheumatoid arthritis, said Genentech spokeswoman Nikki Levy.

``Right now we are reviewing all the data from Olympus and determining next steps regarding our development program,'' Levy said yesterday in an e-mail.

The company still plans a mid-stage clinical trial of ocrelizumab, a second-generation drug that blocks the same protein on B cells as Rituxan. The newer drug will be studied against the relapsing, remitting form of MS, Levy said.

To contact the reporters on this story: Luke Timmerman in San Francisco at ltimmerman@bloomberg.net

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Tuesday

 

TYSABRI Significantly Increased the Proportion of Multiple Sclerosis (MS) Patients Who are Considered Disease Free for Over Two Years

BIOGEN IDEC AND ELAN PRESENT NEW TYSABRI DATA AT THE 60th ANNUAL MEETING OF THE AMERICAN ACADEMY OF NEUROLOGY

Approximately 26,000 Patients on Commercial and Clinical Therapy Worldwide

Additional Analyses Show TYSABRI Significantly Increased the Proportion of Multiple Sclerosis (MS) Patients Who are Considered Disease Free for Over Two Years

Biogen Idec (NASDAQ: BIIB) and Elan Corporation, plc (NYSE: ELN) today announced new data on the global utilization, safety and overall patient exposure of TYSABRI® (natalizumab). As of the end of March 2008, approximately 26,000 patients were on commercial and clinical therapy worldwide with no cases of progressive multifocal leukoencephalopathy (PML) reported since re-launch in the U.S. and launch internationally in July 2006. Growth in global utilization plus increasing confidence in the favorable benefit-risk profile of TYSABRI indicate the companies are making great progress toward the goal of 100,000 patients on therapy by year-end 2010. These data were presented today at the 60th Annual Meeting
of the American Academy of Neurology (AAN).

"These data suggest that neurologists and patients are increasingly choosing TYSABRI for the treatment of their disease. The significant clinical benefits are established and TYSABRI continues to offer the potential for compelling efficacy and hope for those patients living with MS," said Michael Panzara, MD, MPH, Vice President and Chief Medical Officer, Neurology Strategic Business Unit, Biogen Idec.

"Positive outcomes for patients continue to support TYSABRI's strength as a valuable treatment for multiple sclerosis patients in more than 30 countries around the world. We are also excited that patients with Crohn's Disease are now enrolling in the TOUCH program and beginning to receive TYSABRI treatment in the U.S.," said Gordon Francis, MD, Senior Vice President, Global Clinical Development, Elan.

According to data available as of the end of March 2008:
In the U.S., approximately 15,300 patients were on TYSABRI therapy commercially and approximately 2,750 physicians have prescribed the therapy;

Outside of the U.S., more than 10,200 patients were on TYSABRI therapy commercially;
In global clinical trials, more than 600 patients were on TYSABRI therapy; and

There have been no cases of PML since re-launch in the US and launch internationally in July 2006.
Cumulatively, in the combined clinical trial and post-marketing settings:

More than 36,700 patients have been treated with TYSABRI; and

Of those patients, over 9,900 have received at least one year of TYSABRI therapy and more than 3,600 patients have been on therapy for 18 months or longer.

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UPDATE: Rituxan Drug Fails In Key Multiple Sclerosis Trial

BOSTON (Dow Jones) -- A late-stage clinical trial of oncology drug Rituxan failed to show it was effective in treating a certain type of multiple sclerosis, according to Genentech Inc. and Biogen Idec Inc.

Late Monday, Genentech (DNA) and Biogen (BIIB) said that in a Phase II/III trial, Rituxan didn't show the antibody-based medication could effectively slow the progression of primary-progressive multiple sclerosis, or PPMS.

The companies added that currently there are no effective treatments for PPMS, a particularly hard to treat form of the disease.

Rituxan is already approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis.

Biogen Iden markets Avonex, one of the world's best-selling medications for treating multiple sclerosis. The company also co-markets with Elan Corp. (ELN) Tysabri as a multiple sclerosis therapy.

Genentech, a publicly traded division of Swiss conglomerate Roche, is a leading developer of oncology medications.

Biogen Iden markets Avonex, one of the world's best-selling medications for treating multiple sclerosis. The company also co-markets with Elan Corp. (ELN) Tysabri as a multiple sclerosis therapy.

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Drug Fails to Slow Nerve Damage - New York Times

Genentech and Biogen Idec’s cancer drug Rituxan failed to slow the disabling effects of the most difficult form of multiple sclerosis in a large clinical trial, the companies said Monday.

Rituxan failed to reach its main goal of slowing disability for people with primary progressive multiple sclerosis after almost two years of treatment, compared with a placebo, the companies said. If the trial had succeeded, it would have made Rituxan the first drug to work against the primary progressive form of multiple sclerosis.

Rituxan, a blood-cancer drug that is also approved for rheumatoid arthritis, generated $2.29 billion in sales in the United States in 2007. It is designed to work by killing inflammatory B cells, a different approach from approved multiple sclerosis drugs. About 400,000 people in the United States have multiple sclerosis, and one in 10 have the primary progressive form that gradually damages nerve fibers over time without remissions, according to the National MS Society.

”While the primary results are not what we had hoped, we continue to believe in the potential of B cell therapy for patients living with MS,” said Michael Panzara, Biogen’s vice president and chief medical officer of its neurology strategic business unit.

The companies plan to continue analyzing the results and submit them at a medical meeting, the companies said.

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Monday

 

Co-Payments Go Way Up for Drugs With High Prices - New York Times

Health insurance companies are rapidly adopting a new pricing system for very expensive drugs, asking patients to pay hundreds and even thousands of dollars for prescriptions for medications that may save their lives or slow the progress of serious diseases.


With the new pricing system, insurers abandoned the traditional arrangement that has patients pay a fixed amount, like $10, $20 or $30 for a prescription, no matter what the drug’s actual cost. Instead, they are charging patients a percentage of the cost of certain high-priced drugs, usually 20 to 33 percent, which can amount to thousands of dollars a month.

The system means that the burden of expensive health care can now affect insured people, too.

No one knows how many patients are affected, but hundreds of drugs are priced this new way. They are used to treat diseases that may be fairly common, including multiple sclerosis, rheumatoid arthritis, hemophilia, hepatitis C and some cancers. There are no cheaper equivalents for these drugs, so patients are forced to pay the price or do without.

Insurers say the new system keeps everyone’s premiums down at a time when some of the most innovative and promising new treatments for conditions like cancer and rheumatoid arthritis and multiple sclerosis can cost $100,000 and more a year.

But the result is that patients may have to spend more for a drug than they pay for their mortgages, more, in some cases, than their monthly incomes.

The system, often called Tier 4, began in earnest with Medicare drug plans and spread rapidly. It is now incorporated into 86 percent of those plans. Some have even higher co-payments for certain drugs, a Tier 5.

Now Tier 4 is also showing up in insurance that people buy on their own or acquire through employers, said Dan Mendelson of Avalere Health, a research organization in Washington. It is the fastest-growing segment in private insurance, Mr. Mendelson said. Five years ago it was virtually nonexistent in private plans, he said. Now 10 percent of them have Tier 4 drug categories.

Private insurers began offering Tier 4 plans in response to employers who were looking for ways to keep costs down, said Karen Ignagni, president of America’s Health Insurance Plans, which represents most of the nation’s health insurers. When people who need Tier 4 drugs pay more for them, other subscribers in the plan pay less for their coverage.

But the new system sticks seriously ill people with huge bills, said James Robinson, a health economist at the University of California, Berkeley. “It is very unfortunate social policy,” Dr. Robinson said. “The more the sick person pays, the less the healthy person pays.”

Traditionally, the idea of insurance was to spread the costs of paying for the sick.

“This is an erosion of the traditional concept of insurance,” Mr. Mendelson said. “Those beneficiaries who bear the burden of illness are also bearing the burden of cost.”

And often, patients say, they had no idea that they would be faced with such a situation.

It happened to Robin Steinwand, 53, who has multiple sclerosis.

In January, shortly after Ms. Steinwand renewed her insurance policy with Kaiser Permanente, she went to refill her prescription for Copaxone. She had been insured with Kaiser for 17 years through her husband, a federal employee, and had had no complaints about the coverage.

She had been taking Copaxone since multiple sclerosis was diagnosed in 2000, buying 30 days’ worth of the pills at a time. And even though the drug costs $1,900 a month, Kaiser required only a $20 co-payment.

Not this time. When Ms. Steinwand went to pick up her prescription at a pharmacy near her home in Silver Spring, Md., the pharmacist handed her a bill for $325.

There must be a mistake, Ms. Steinwand said. So the pharmacist checked with her supervisor. The new price was correct. Kaiser’s policy had changed. Now Kaiser was charging 25 percent of the cost of the drug up to a maximum of $325 per prescription. Her annual cost would be $3,900 and unless her insurance changed or the drug dropped in price, it would go on for the rest of her life.

“I charged it, then got into my car and burst into tears,” Ms. Steinwand said.

She needed the drug, she said, because it can slow the course of her disease. And she knew she would just have to pay for it, but it would not be easy.

“It’s a tough economic time for everyone,” she said. “My son will start college in a year and a half. We are asking ourselves, can we afford a vacation? Can we continue to save for retirement and college?”

CLICK BELOW FOR FULL STORY:


Co-Payments Go Way Up for Drugs With High Prices - New York Times

Labels:


Sunday

 

These are the last 100 posts I've made on my MySpace page...



LOST MY MEDICAID, MY JOB...SUFFERED WITH PROGRESSIVE MS EVERYDAY FOR 2 YEARS

LOST MY MEDICAID, MY JOB...SUFFERED WITH PROGRESSIVE MS EVERYDAY FOR 2 YEARS



I WANT OUT: I&#8217;ve been dealing with DEEP DEPRESSION-my grandmas death-my grandpas alzheimers....

I WANT OUT: I’ve been dealing with DEEP DEPRESSION-my grandmas death-my grandpas alzheimers....



after being a member of the ambulance for 12 years, Im taking the EMT course! Wish me luck!

after being a member of the ambulance for 12 years, Im taking the EMT course! Wish me luck!



My MS has been going haywire because my roommate &amp; best friends ex wife is a vindictive person

My MS has been going haywire because my roommate & best friends ex wife is a vindictive person



I just wanted to share that I had my first shot today and it seems to have went well

I just wanted to share that I had my first shot today and it seems to have went well



&quot;Tidying the House Soothes Mental Distress by 24%&quot;

"Tidying the House Soothes Mental Distress by 24%"



The MySpace Archive&#8217;s Do not work...

The MySpace Archives Do not work...



Im Feeling Defeated-I just started a new job-Since starting I have fatigue &amp; migraine headaches

I'm Feeling Defeated-I just started a new job-Since starting I have fatigue & migraine headaches



I finally have mom in a good way-she doesnt have to feel bad anymore like shes an inconvenience

I finally have mom in a good way-she doesnt have to feel bad anymore like shes an inconvenience



&quot;The Perfect Gift&quot; - Christina

"The Perfect Gift" - Christina



I&#8217;ve started a new relationship &amp; I&#8217;m paying the price: 1 night out=2 days of being a vegetable

I’ve started a new relationship & I’m paying the price: 1 night out=2 days of being a vegetable



(Tysabri-Pot-Vitamins) The pain has lessoned so much that I&#8217;m dancing again..I had energy -Tina

(Tysabri-Pot-Vitamins) The pain has lessoned so much that I’m dancing again..I had energy -Tina



I got a new job stan - Amber

I got a new job stan - Amber




(UPDATE).....I’m just asking for hugs, prayers, or some words of encouragment.



(BREAKING NEWS) &quot;Copaxone Significantly Reduced Annual Relapse Rates &amp; Stabilized Disease Pro..

(BREAKING NEWS) "Copaxone Significantly Reduced Annual Relapse Rates & Stabilized Disease



I&#8217;m getting pretty depressed-I broke up with my girlfriend..could it be the MS medicines I take

I’m getting pretty depressed-I broke up with my girlfriend..could it be the MS medicines I take



this past Saturday I was apart of my very first MS Walk.

this past Saturday I was apart of my very first MS Walk.



does anyone take Rebif &amp; Tysabri both? &amp; how do you feel about it? anyone heard of Devics Syndr

does anyone take Rebif & Tysabri both? & how do you feel about it? anyone heard of Devics Synd



PLEASE PRAY FOR ME...I will not let MS, or being Single stand in my way..GOD BLESS YOU ALL !!!

PLEASE PRAY FOR ME...I will not let MS, or being Single stand in my way..GOD BLESS YOU ALL !!!



Thanks Stan &amp; everyone for the hugs &amp; thoughts-It means a lot-It&#8217;s good to know I&#8217;m not alone

Thanks Stan & everyone for the hugs & thoughts-It means a lot-It's good to know I'm not alone



(BREAKING NEWS: NEW MS DRUG FOR WOMEN ONLY) &quot;Study uses hormones to treat multiple sclerosis&quot;

(BREAKING NEWS: NEW MS DRUG FOR WOMEN ONLY) "Study uses hormones to treat multiple sclerosis"



The Blog averages about 1,000 visitors each day....BUT

(UPDATE)....The Blog averages about 1,000 visitors each day....BUT



INTERESTING STUDY ON ALCOHOL &amp; MISSED DOSES OF MS MEDS - stan

INTERESTING STUDY ON ALCOHOL & MISSED DOSES OF MS MEDS - stan



i just made the dance team!!!

i just made the dance team!!!



(CINDI&#8217;S DR UPDATE)...I don&#8217;t know what to do anymore...I just wanna give up and say screw it!!

(CINDI'S DR UPDATE)...I don't know what to do anymore...I just wanna give up and say screw it!!



I would like to know if you would add me I have had M. S. since 86 was dg in 97

I would like to know if you would add me I have had M. S. since 86 was dg in 97



The muscle relaxant has taken the edge of the predisone so I&#8217;m not itchy anymore

The muscle relaxant has taken the edge of the predisone so I'm not itchy anymore



I&#8217;ve seen improvement with Tysabri but Physical Therapy has helped immensely

I've seen improvement with Tysabri but Physical Therapy has helped immensely



&quot;Physician battling multiple sclerosis shares her story&quot; -Minneapolis Star Tribune

"Physician battling multiple sclerosis shares her story" -Minneapolis Star Tribune



Have any of the angels mentioned loosing taste buds? I&#8217;m loosing mine &amp; I wondered if it&#8217;s MS

Have any of the angels mentioned loosing taste buds? I'm loosing mine & I wondered if it's MS



I would like to share the benefits of cranberry juice with you &amp; our friends

I would like to share the benefits of cranberry juice with you & our friends



I have heard wonderful things about your page Stan...I was only diagnosed in January

I have heard wonderful things about your page Stan...I was only diagnosed in January



But im scared-i dont understand how life can be so cruel to a child!!!!!

But im scared-i dont understand how life can be so cruel to a child!!!!!



Molly&#8217;s poem might help you: &quot;convince those they love most that MS isn&#8217;t all in your head&quot;

Molly's poem might help you: convince those they love most that MS isn't all in your head



BECAUSE OF YOU &amp; THIS SITE &amp; THE ANGELS, I FEEL I CAN TAKE ON THE WORLD &amp; MAKE IT THROUGH.....

BECAUSE OF YOU & THIS SITE & THE ANGELS, I FEEL I CAN TAKE ON THE WORLD & MAKE IT THROUGH....



I did it..Yesterday I walked the MS Walk..I walked the entire 5.5 miles -Nena

I did it..Yesterday I walked the MS Walk..I walked the entire 5.5 miles -Nena



They told me I need to start chemo-I am very scared and depressed about the thought of that!

They told me I need to start chemo-I am very scared and depressed about the thought of that!



Stan,We Might Have Some Good News! Diagnosed Joe with MS might have made a mistake

Stan, We Might Have Some Good News! Diagnosed Joe with MS might have made a mistake



WOW...You gave our Friends 238 Hugs/Kudos yesterday - stan

WOW...You gave our Friends 238 Hugs/Kudos yesterday - stan





THIS IS NOT ABOUT MS...BUT IT IS ABOUT THE COMPANY THAT MAKES TYSABRI...

THIS IS NOT ABOUT MS...BUT IT IS ABOUT THE COMPANY THAT MAKES TYSABRI...



I&#8217;m just asking for hugs, prayers, or some words of encouragment.

I’m just asking for hugs, prayers, or some words of encouragment.



it has been 35 days since I had a Tysabri infusion and can I tell and feel the difference..

it has been 35 days since I had a Tysabri infusion and can I tell and feel the difference..



Fatigue is really being a bother-I&#8217;d like to know if any angels have had a sleep stud

Fatigue is really being a bother-I'd like to know if any angels have had a sleep study



I wanted to ask the angels to please remember my daddy,,He is going to a MS clinic

I wanted to ask the angels to please remember my daddy,,He is going to a MS clinic



THIS IS A GOOD VIDEO ON GIVING AN AVONEX INJECTION...send me yours &amp; I'll post them too - stan

THIS IS A GOOD VIDEO ON GIVING AN AVONEX INJECTION...send me yours & I'll post them too - stan



DO YOU HAVE A &quot;NEURO-NIGHTMARE STORY&quot; LIKE DARA&#8217;S???

DO YOU HAVE A "NEURO-NIGHTMARE STORY"; LIKE DARA'S???



(News) MS &amp; HEAT

(News) MS & HEAT



Many Angels have asked me to have hats designed...so...here&#8217;s the initial design:

Many Angels have asked me to have hats designed...so...here’s the initial design:



I saw my nero. She gave me 2 thumbs up -Susan

I saw my nero. She gave me 2 thumbs up -Susan



I asked John to leave...he has never been very supportive in my MS

(UPDATE 2)...I asked John to leave...he has never been very supportive in my MS



Why is it that when you have MS and you can&#8217;t work people think your lazy?

Why is it that when you have MS and you can't work people think your lazy?



I would like to let the angles know i need a support system, i don&#8217;t have any friends with MS

I would like to let the angles know i need a support system, i don't have any friends with MS



I just got diagnosed with MS on March 28th -Sidonia

I just got diagnosed with MS on March 28th -Sidonia



I&#8217;m not doing good Stan..I&#8217;m having digestion and migraines do to emotional &amp; physical stress

I'm not doing good Stan..I'm having digestion and migraines do to emotional & physical stress



Is Leona&#8217;s Doctor crazy or am I? I THOUGHT IT WAS A MEDICAL FACT THAT MS CAN CAUSE PAIN -stan

Update ~ Is Leona’s Doctor crazy or am I? I THOUGHT IT WAS A MEDICAL FACT THAT MS CAN CAUSE PAIN -stan



I&#8217;ve had MS since I was 14-it sucks! I don&#8217;t feel like any of my friends &amp; family understand me

I've had MS since I was 14-it sucks! I don't feel like any of my friends & family understand me



My ongoing issue is keeping the optic nerve from causing problems-My memory is good some days..

My ongoing issue is keeping the optic nerve from causing problems-My memory is good some days..



BREAKING NEWS...(but is it laughable or important: &quot;Man-cow hybrid embryo creates row&quot;

BREAKING NEWS...(but is it laughable or important): "Man-cow hybrid embryo creates row"



Stan I am going crazy-I ask for something to help with pain-she says wait till next appt

Stan I am going crazy-I ask for something to help with pain-she says wait till next appt



Jason broke up with because of the MS-i hate myself-Im sad-depressed-MS ruins everything

Jason broke up with me because of the MS-i hate myself-Im sad-depressed-MS ruins everything



I just wanted to thank you for posting a blog about Hannah

I just wanted to thank you for posting a blog about Hannah



I&#8217;m disappointed..I wanted to do the MS Walk..I have a Tysabri infusion the morning of the walk

I'm disappointed..I wanted to do the MS Walk..I have a Tysabri infusion the morning of the walk



Wonderful Words of Wisdom from Kimberly

Wonderful Words of Wisdom from Kimberly



Could anyone who is on Copaxone please let me know when they started feeling better from it?

(UPDATE)...Could anyone who's on Copaxone let me know when they started feeling better from it?



I went to my pcp &amp; brought up the neuro issue=thanks to all the angels that keep pushing me

I went to my pcp & brought up the neuro issue=thanks to all the angels that keep pushing me



we are also planning our last baby..She said even after the 1st dose Novatrone can cause Cancer

we are also planning our last baby..She said even after the 1st dose Novatrone can cause Cancer



a bit about my journey to my MS dx -Jessica

a bit about my journey to my MS dx -Jessica



&quot;Managing Work and MS: an employment teleconference series throughout April&quot;

"Managing Work and MS: an employment teleconference series throughout April"



Our OhioAngel needs congrats...plus good-luck-finding-job-prayers....STAN

Our Ohio Angel needs congrats...plus good-luck-finding-job-prayers....STAN



I think I should give up on people,so I wont have to worry about disappointment or loosing them

I think I should give up on people,so I wont have to worry about disappointment or loosing them



&quot;I accept...I fear...I reject...I hope...&quot; - MEGAN

"I accept...I fear...I reject...I hope..." - MEGAN



I just got done with a 3-day SoluMedrol run..I managed to pull an &#8217;April Fools&#8217; on the MonSter

I just got done with a 3-day SoluMedrol run..I managed to pull an ’April Fools’ on the MonSter



My grandfather died in his sleep last night..I&#8217;m so sad..I&#8217;m really gonna miss him! -LISA

My grandfather died in his sleep last night..I’m so sad..I’m really gonna miss him! -LISA



My grandmother passed away this a.m. - TINA

(UPDATE)......My grandmother passed away this a.m. - TINA



I&#8217;m wondering if any of the Angels have experienced these symptoms while on Lexapro:

I’m wondering if any of the Angels have experienced these symptoms while on Lexapro:



(NEWS) &quot;Fatigue in MS&quot; - Eileen

(NEWS) "Fatigue in MS" - Eileen



I started smoking pot-NOW I&#8217;M ABLE TO DO THINGS: I&#8217;ve been walking around the lake-and NO PAIN!

I started smoking pot-NOW I’M ABLE TO DO THINGS: I’ve been walking around the lake-and NO PAIN!



- :-)

:-) HAPPY APRIL FOOLS DAY!!



i need a hug..IM SO TRIED OF PEOPLE JUDGING MY ILLNESS BY HOW I LOOK-i want to give up but...

i need a hug..IM SO TIRED OF PEOPLE JUDGING MY ILLNESS BY HOW I LOOK-i want to give up but...



BREAKING NNEWS FROM THE FDA: Possible Association Between Use Of Singulair...And Suicide

BREAKING NEWS FROM THE FDA: Possible Association Between Use Of Singulair...And Suicide



It&#8217;s a girl!! I am going to be a grandma - Laura

It’s a girl!! I am going to be a grandma - Laura



today i feel really lost and alone..ive been experiencing things with my body i keep to myself

today i feel really lost and alone..ive been experiencing things with my body i keep to myself



STAN CHECK THIS OUT: &quot;Gene sweeps yield discoveries&quot; - LISA

STAN CHECK THIS OUT: "Gene sweeps yield discoveries" - LISA



my mom has ms..i have a very hard time dealing with it bc i can&#8217;t stand 2 c her in so much pain

my mom has ms..i have a very hard time dealing with it bc i can’t stand 2 c her in so much pain



I am terrified! Appointment with the Pulmonologist tomorrow..So please keep me in your thoughts

I am terrified! Appointment with the Pulmonologist tomorrow..So please keep me in your thoughts



I thought that some of you might like to know that Tysabri website has been revamped -Lauren

I thought that some of you might like to know that Tysabri website has been revamped -Lauren



Hope you&#8217;re having a GREAT weekend...I am now that my leg is working again;)

Hope you’re having a GREAT weekend...I am now that my leg is working again;)



I need some hugs and listening ears of those who truly understand what MS is

I need some hugs and listening ears of those who truly understand what MS is



Im doing ok but find myself at home feeling somewhat sorry for myself ,,,,,

Im doing ok but find myself at home feeling somewhat sorry for myself ,,,,,



I still have pneumonia and getting worse..

I still have pneumonia and getting worse..



SAD &amp; SCAREY STUDY-Most Patients arent going to Neuros &amp; are getting the wrong treatment

SAD & SCAREY STUDY-Most Patients arent going to Neuros & are getting the wrong treatment



My life is over-what do you do when you find out you have been cheated on???

My life is over-what do you do when you find out you have been cheated on???



Im ready to give up-Lots of prayers is what I&#8217;m asking for from the wonderful MS angels

Im ready to give up-Lots of prayers is what I’m asking for from the wonderful MS angels



You invite it (Avonex depression) in like an old friend-let it stay a while then kick it out

You invite it (Avonex depression) in like an old friend-let it stay a while then kick it out



the nuero looked at my mri...he wants to pull me off my rebif and put me on tysabri

the nuero looked at my mri...he wants to pull me off my rebif and put me on tysabri



&quot;Free Hoyer Lift with sling-Nothing is wrong with it, just needed to get a portable one&quot;

"Free Hoyer Lift with sling-Nothing is wrong with it, just needed to get a portable one"



&quot;The Autoimmune Epidemic: Bodies Gone Haywire in a World Out of Balance&quot; =SARAH

"The Autoimmune Epidemic: Bodies Gone Haywire in a World Out of Balance" =SARAH



im sad-i need help-i need advise-i need support-ive been crying for days-now im scared

Update ~ im sad-i need help-i need advise-i need support-ive been crying for days-now im scared



I&#8217;m curious if anyone else has experienced weight loss with MS - Misty

I’m curious if anyone else has experienced weight loss with MS - Misty



I am begging your Angels to pray...I&#8217;m was getting worse everyday.

I am begging your Angels to pray...I’m was getting worse everyday.



My MS Video Stan: &quot;I am a soldier&quot; - MEG

My MS Video Stan: "I am a soldier" - MEG



I deal with chronic everything! Chronic-depression,chronic-fatigue, chronic-life! hahahahahaha

I deal with chronic everything! Chronic-depression,chronic-fatigue, chronic-life! hahahahahaha



I was DXed 3 1/2 years ago. my wife is one of your friends so I thought I should join - Joe

I was DXed 3 1/2 years ago. my wife is one of your friends so I thought I should join - Joe



Important Social Security /Disability Info. - Cindi

Important Social Security /Disability Info. - Cindi



she wrote &quot;This patient have no fatiuge at this time.&quot; Oh bullhockey!!!

she wrote "This patient have no fatiuge at this time." Oh bullhockey!!!



The cat&#8217;s outta&#8217; the bag - eRsILiA

The cat’s outta’ the bag - eRsILiA



I&#8217;m asking for some hugs, positive thoughts and some major prayers sent my way please

I’m asking for some hugs, positive thoughts and some major prayers sent my way please



the angels have helped me so much!!! - Christina

...the angels have helped me so much!!! - Christina



Ive lost 54 pounds-I&#8217;d like to start running-the fact that I have MS makes me determined to try

Ive lost 54 pounds-I’d like to start running-the fact that I have MS makes me determined to try



After reading Sheena&#8217;s story of discrimination, I felt compelled to tell my story as well - Kim

After reading Sheena’s story of discrimination, I felt compelled to tell my story as well - Kim



Our Friend Pie plans to go off meds &amp; &quot;start trying for a kid&quot; soon

Our Friend Pie plans to go off meds & "start trying for a kid" soon



Hannah needs our hugs right this second &amp; her Mom needs our support - stan

Hannah needs our hugs right this second & her Mom needs our support - stan



Do any of the Angels have depression...Bipolar etc &amp; still take one of the drugs for FATIGUE???

Do any of the Angels have depression...Bipolar etc & still take one of the drugs for FATIGUE???



I have been EXTREMELY ILL with the MS funk and had to seek more intensive help -Jay

I have been EXTREMELY ILL with the MS funk and had to seek more intensive help -Jay



(AVONEX PROBS) I have an appt with my neuro in the morning to discuss another treatment -Cindi

(AVONEX PROBS) I have an appt with my neuro in the morning to discuss another treatment -Cindi



I am so scared! I had my disability dr appointment..I started crying in the appt - Mandi

I am so scared! I had my disability dr appointment..I started crying in the appt - Mandi



jealousy is such a waste of a human emotion-i don&#8217;t understand it-especially in relationships

jealousy is such a waste of a human emotion-i don’t understand it-especially in relationships



&quot;Fatigue in MS&quot; (from the National MS Society)

"Fatigue in MS" (from the National MS Society)



&quot;What is normal&quot; - MEG

"What is normal" - MEG



HAPPY EASTER TO ALL MY WONDERFUL ANGELS

HAPPY EASTER TO ALL MY WONDERFUL ANGELS



I need hugs &amp; prayers-I found out a short time ago that I have MS-Im having a hard time dealing

I need hugs & prayers-I found out a short time ago that I have MS-Im having a hard time dealing

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