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Thursday

 
Alek was relieved she was diagnosed with MS 

"I WAS AFRAID I HAD A BRAIN TUMOR"
A student who feared she had a brain tumor told of the agonising wait she faced while doctors worked to diagnose her condition.
Read more »

 
2 NEW MIGRAINE DRUGS ARE THE 1ST EVER THAT WORK TO PREVENT RATHER THAN SIMPLY TREAT MIGRAINES: STUDY SAYS THEY WORK

Two drugs given to people who suffer migraines reduced the frequency of their headaches in early trials, scientists said.
The test results “may potentially represent a new era in preventive therapy for migraine,” Dr. Peter Goadsby, an author on studies of both drugs, said in a statement.
Read more »

 

After a simple, modified Paleo diet reversed her multiple sclerosis, one doctor is saying: Prescriptions don’t make you well.

 

New data at AAN meeting of Neurologists to confirm efficacy of Novartis' Gilenya across four key measures of MS disease activity, including brain volume loss

 

Biogen beats revenue estimates as Tecfidera hits blockbuster status

 

Review of current MS treatments for physicians

 
POOR ARE AT GREATER RISK OF DEVELOPING MS

Adverse socioeconomic position (SEP), in both childhood and adulthood, is associated with a susceptibility to developing multiple sclerosis (MS), adding to the growing evidence linking lower SEP to a range of poorer health outcomes, according to a Californian study.

Factors associated with the risk of MS include parents renting versus owning a home, not having a college-level education and low social mobility. The authors conclude that “both genetic and environmental contributions to chronic conditions are important and must be characterised to fully understand MS aetiology”.

Story Source: The above story is based on materials provided by 
OCCUPATIONALHEALTH
Note: Materials may be edited for content and length

Briggs FBS et al (2014). “Adverse socioeconomic position during the life course is associated with multiple sclerosis”. Journal of Epidemiology & Community Health, first published online 27 February.

 

NEUROANATOMY & MS ARE TURNED ON THEIR HEAD BY NEW HARVARD FINDING

Harvard neuroscientists have made a discovery that turns 160 years of neuroanatomy on its head.
Myelin, the electrical insulating material long known to be essential for the fast transmission of impulses along the axons of nerve cells, is not as ubiquitous as thought, according to a new work lead by Professor Paola Arlotta of the Harvard Stem Cell Institute (HSCI) and the University’s Department of Stem Cell and Regenerative Biology, in collaboration with Professor Jeff Lichtman, of Harvard’s Department of Molecular and Cellular Biology.

“Myelin is a relatively recent invention during evolution,” says Arlotta. “It’s thought that myelin allowed the brain to communicate really fast to the far reaches of the body, and that it has endowed the brain with the capacity to compute higher level functions.” In fact, loss of myelin is a feature of a number of devastating diseases, including multiple sclerosis and schizophrenia.

But the new research shows that despite myelin essential roles in the brain, “some of the most evolved, most complex neurons of the nervous system have less myelin than older, more ancestral ones” Arlotta, co-director of the HSCI neuroscience program, says.

What this means, Arlotta says, is that the higher in the cerebral cortex one looks – the closer to the top of the brain, which is its most evolved region – the less myelin one finds. Not only that, but “neurons in this part of the brain display a brand new way of positioning myelin along their axons that has not been previously seen. They have ‘intermittent myelin’ with long axon tracts that lack myelin interspersed among myelin-rich segments.

Read more »

Wednesday

 

Important message from Beth Dean

I've written 15 Columns for you!
Read them by clicking on my 
photo on the far left
side of this page

IF YOU READ MSnewsChannel EVERY DAY: YOU DON'T NEED TO SIGN UP FOR OUR "DRUG ALERTS"  BUT IF YOU DON'T VISIT HERE EVERY DAY: CLICK THE FLASHING BUTTON BELOW


Thank You,
Beth Dean
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 Columnist, MSnewsChannel.com
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MS Patient, Ph.D.: A Pregnant Pause



My own experience suggests that awareness of MS’s impact on pregnancy is either low or outdated within the obstetrics community


One of the first people I told that I was pregnant, aside from my parents and in-laws, was my doctor. Of course you expect to tell your obstetrician (OB), or at least ask them to confirm the home pregnancy test. But most women outside of the MS community, I presume, would be surprised to be discussing reproductive health with a neurologist.

In fact, we had already had a conversation months earlier, even before I talked to my OB about it, about planning the discontinuation of my disease-modifying therapy (DMT) before trying to conceive. We talked in-depth about keeping track of my health sans DMT, timing the next visit and whether an MRI would be taken before then. Luckily, I got pregnant right away, so my worries about having a new relapse while off DMT and before the mysterious protective effects of pregnancy kicked in didn't come to fruition.

Early on after my diagnosis, I had been comforted by the fact that I could expect a standard pregnancy. My OBs didn't seem to be aware of this fact. And maybe they aren’t, since the major shift in recommendation about MS women becoming pregnant only happened 16 years ago, when the Pregnancy and Multiple Sclerosis study results were first published (Confavreux et al., 1998). Rather, they seemed especially intimidated by me as a patient, even though I had only experienced one sensory relapse and was otherwise pretty healthy. (Read: I'm sure there are other patients to worry more about.)

My OB was so anxious about me that he pushed me to have a consult with the anesthesiologist ahead of time, possibly due to outdated research (Bader et al., 1988) that had correlated high concentrations of anesthetic with increased relapse rate. This was not necessary since epidurals don’t affect the rate of relapse (Confavreux et al., 1998) or cause any specific issues in patients with MS. Reassured that there were negligible risks versus the general population, I ended up just talking to them on the phone about my own concerns about an epidural, which were unrelated to the fact that I have MS.

I also saw a fetal medicine specialist at the request of my concerned OB, which basically flagged my pregnancy as “high-risk.” This specialist did more ultrasounds than normal but also wasn't terribly concerned with my MS, although she warned me that there was a higher chance of me having a cesarean section, which is somewhat controversial (Lu et al., 2013) but didn't happen to me anyway. In the end, I had a lot more office visits and extra tests than a standard pregnancy would require—which added to the cost of healthcare and the amount of time that I had to take to go to the extra visits. There's more I can say about my pregnancy and breastfeeding experiences, but I'll leave that for another post.

I will say, I'm pretty happy with how supportive my neurologists were about me having a baby—and, of course, the research supports this stance (Vikusic and Confavreux, 2006) They kept me relaxed during the pregnancy, especially when I repeatedly asked what to do if I had a relapse while pregnant. (Short answer: We will cross that bridge when we come to it; it will depend a lot on all the variables.)

Instead of offering the same support that my neurologists did, my OB seemed pretty uneasy about seeing a pregnant lady with MS—not something that was comforting as an already paranoid first-time mother. This is unfortunate since as infrequent as MS is in the total population, it emerges in women of childbearing age the most often. I was not impressed by the lack of knowledge or, at best, outdated knowledge from my OB about pregnancy with MS. The easiest (quickest?) solution for this issue might be for neurologists to take a more proactive and holistic approach with their patient by contacting a patient’s OB to calm their fears and address their concerns.

Story Source: The above story is based on materials provided by MULTIPLE SCLEROSIS DISCOVERY FORUM
Note: Materials may be edited for content and length
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HAROLD RECEIVED POSITIVE RESULTS WITH LEMTRADA BUT IS DISAPPOINTED THE FDA WON'T APPROVE IT

 

Dual Nerve Stimulation Helps Chronic Migraine

 

Full steam ahead for Copaxone copies as SCOTUS denies Teva's bid for delay

 

A specially designed, inexpensive insole could help boost the walking ability of MSers

 

"I HAVE NEVER BEEN MORE SCARED AND NERVOUS IN MY LIFE," LASHAE

 

NEW MS DRUG CANDIDATE LENALDEKAR COMES FROM ZEBRAFISH


Multiple sclerosis and acute lymphoblastic leukemia (ALL) have something in common: too many T cells. In MS, those T cells are directed against components of myelin. In ALL, immature T cells build up. So it makes sense that compounds that would lower the number of errant T cells in leukemia might also do so for MS.

That’s exactly what researchers reported in the April 2014 issue of PLOS ONE (Cusick et al., 2014). But the shared characteristic of the two diseases—which are otherwise very different—nearly derailed the development trajectory of the MS drug candidate, Lenaldekar (LDK). Fortunately, it’s back on track, with very promising results in a mouse model.

Read more »

 

Quantitative assessment of upper limb motor function in Multiple Sclerosis using an instrumented Action Research Arm Test

 

Gilenya helps Alzheimers

 
TOP HOSPITAL OFFERS CHINESE HERBS AS MEDICINE 
Evidence is lacking that herbs are effective
At the Cleveland Clinic, herbalist Galina Roofener meets with patient John McGeehan, who complains of chronic nausea.
Read more »

Tuesday

 
Sativex spray is waiting for final FDA approval

THIS POT GROWING FACILITY PRODUCES 20 TONS OF POT EACH YEAR USED IN SATIVEX SPRAY WHICH IS USED TO TREAT MS SPASTICITY
This secret marijuana-growing facility that produces 200 tons of raw material and about 20 tons of actual pot each year. (The facility is reportedly guarded around the clock, and each plant is genetically fingerprinted to enable tracking, should anything be stolen.) From these plants, the key components of GW’s cannaboid products are carefully extracted and standardized. ”It’s not just street cannabis put into a bottle,” CEO Justin Gover told the Guardian in 2011. “To get regulatory approval, we had to meet very strict standards. We had to know every vial of Sativex is identical.”

Read more »

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Beth Dean, Columnist and Drug Alert Editor, MSnewsChannel.com

I've written 15 Columns for you!
Read them by clicking on my 
photo on the far left
side of this page

DATING IN GENERAL SUCKS: DATING WITH MS IS TOUGH!

All kinds of things to think about, ponder over…Should I tell them up front, should I wait? What if they get scared or think I’m weird? Will they think they can catch it, will it matter? It’s all very frustrating to say the least! I think one of the big things for me was the physical limitations I was dealing with. 

I was so embarrassed for anyone to see me walk, try to put my hair in a ponytail…even stand still for any amount of time because my legs would start shaking uncontrollably! Because of all of these factors and because I was freshly diagnosed and still dealing with it myself, I just avoided it all together! I talked to men, but at all costs I avoided meeting them in person! When I finally come to grips with the fact that I’ll have this disease for life, and this is who I am now…things got a little easier.
Read more »

 

Paul will undergo autologous haematopoietic stem cell transplant in Russia to fight multiple sclerosis

 

Umbilical Cord Stem Cell Therapy Clinical Trial for Multiple Sclerosis Gets Green Light

 

Gilenya leads to rare disease in patient

 

MSers pay less now for Illinois medical marijuana patient card: $100

 

Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS

 

Sexual health and aging: Keep the passion alive - Mayo Clinic


Sexual feelings don't disappear as you age. Here's how to keep the flame burning.

Read more »

 

Natco Pharma surges as US court allows Generic Copaxone launch

 

CMS—Engaging Multiple Payers in Payment Reform: Journal of the American Medical Association

 

Update

THE FATIGUE THAT MSers EXPERIENCE IS VERY DIFFERENT FROM THE TYPE EXPERIENCED BY HEALTHY PEOPLE

Victoria M. Leavitt, Ph.D., neuropsychologist & co-founder of the Manhattan Memory Center 



“When I share my research on fatigue in MS with colleagues or friends,” Victoria M. Leavitt, Ph.D., a neuropsychologist and co-founder of the Manhattan Memory Center in New York City told Healthline, “they say they know what it’s like, but the truth is they don’t.”
MS fatigue usually occurs every day, with lack of energy peaking by mid-afternoon. Onset can be sudden and is aggravated by heat.
Read more »

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Monday

 

23 HEALTH BENEFITS OF MEDICAL MARIJUANA

In Tuesday's news

 

BREAKING NEWS: TEVA WANTS TO PAY $500,000,000 TO STOP GENERIC COPAXONE FROM BEING SOLD IN US

 

BUDDY ALLEN WANTS & NEEDS LEMTRADA




When Robert “Buddy” Allen could no longer run after a Frisbee, he thought the cause was an old childhood injury -- when he got hit by a car. A neurologist, a chiropractor and an orthopedic surgeon all weighed in on Allen’s symptoms, which included tightness in his right leg and an overall stiffness in his body, but no one could pinpoint the culprit.

Read more »

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Incontinence-related quality of life improved significantly during Tysabri

"Blocking inflammation in the CNS does not just stop relapses, it can improve fatigue in some people and as shown here can help with bladder function also..."
  • UDI-6 and IIQ-7 scores were significantly improved in patients with MS following natalizumab treatment.
  • The majority of patients showed improvement or stability in number of incontinence episodes per week and in number of micturitions per day after starting natalizumab.
  • Natalizumab may reduce the impact of incontinence on QOL.

HERE'S THE STUDY:

Read more »

 

BREAKING NEWS: Pfizer considers $100 billion bid for AstraZeneca

 

The pitfalls of giving free medical advice to Family and Friends

There are some situations for which medical school simply doesn't prepare you. Consider Thanksgiving dinner, when Aunt Myrtle buttonholes you about a recurring rash that's been bothering her. Or the sideline consult that one of the parents at your kid's football game wants to have, right after her son lands awkwardly trying to catch a pass.
Click to read: you will need your Medscape Physicians password

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A Drop at a Time: How Cannabis Oil is Changing Lives of Cancer Patients in the UK

 

Do MS patients and proxies agree? Study

 

After being diagnosed with MS, Lori started caring for rescued exotic animals to pass the time.
"My doctor told me to get a hobby"
Read more »

 

A message from the Editor of MSnewsChannel.com


Here's a few of the FeatureStories we're working on for you: we will be posting 1 or 2 tomorrow & every day (usually) 7 days a week:
  • HISTORY OF STEM CELLS: 15 PHOTO SLIDESHOW
  • THE BEGINNING OF RICHARD COHEN'S STEM CELL JOURNEY
  • What is a TENS machine? It might help MS
  • MSer will swim 10-11 hours across lake
  • Stressful life-events in childhood and risk of MS: Parental divorce is somehow associated with modestly increased risk of MS
  • Legalize Medical Marijuana, Doctors Say in Survey! Neurologists reported the highest number of patients asking if medical marijuana might help the.
  • NEW STUDY: MEDS HELP IMPROVE MSers STANDING BALANCE
  • From Plant to Prescription: 5 Ways Marijuana Made It to the Market
  • Pregabalin an Effective Alternative for Restless Legs Syndrome
  • TYSABRI AS "1ST-LINE" TREATMENT FOR MS
  • MARY TELLS ABOUT: “It was amazing...I was so thrilled that it gave my body the feelings it had pre-MS.”
  • MS IS A DISCRIMINATORY DISEASE
  • HOW THIS SUICIDE RELATES TO MSers: "The topic of suicide was thrust into the headlines recently with the death of L'Wren Scott, a fashion designer whose March 17 death was ruled a suicide by police"
  • THE BEST WAY TO QUIT SMOKING THAT YOU HAVE NEVER READ ABOUT
  • Can the bacteria in the GI Tract affect MS? 
  • CHILD NAMED ROTEM WAS INSPIRATION FOR AN INVENTION THAT ALLOWS MOBILITY-CHALLENGED LITTLE ONES TO EXPERIENCE WALKING
  • PLUS MANY MORE!!

Editor
Stan Swartz

PS...Have a Story or Study you want posted? Or are you a Neurologist or Nurse and want to share some advice? e-mail at: stanswartz@mac.com
  • We posted 5,560 Stories for Doctors, Nurses & Savvy MSers in 2013
  • We're building the 12 MS Drug Treatment Channels at the top of this page & hope to finish them by June 1, 2014!
  • Our 32 Columnists have written 210 articles for you since we started the Columns 3 months ago
  • News is posted at Midnight 7 days a week
  • 180,618 VISITORS! 

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Cindi Hopper Columnist MSNewsChannel.com



MY COLUMN WILL MAKE YOU BOTH ROTFL AND CRY! PLUS: I'LL TELL YOU WHAT GIFT YOU NEED TO BUY YOURSELF: IT HELPS ME FIGHT THE MONSTER

If there’s one thing those of us that have been diagnosed with Multiple Sclerosis or any other “invisible illness” as I like to call it do, its improvise. We have to “suck it up” a lot around non believing friends and family members more times than not just because of ignorance and unawareness.
Read more »

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CALIF. DOC WITH 'MULTIPLE SCLEROSIS CURE' GETS 14 YEARS PRISON

Daniel used her position both as a doctor at the Sonrise Wellness Center and a Pentecostal minister to
Read more »

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Woman finds new life through MS

MS MADE ME A BETTER MOM

"Jasmine Winkelman is thankful she got multiple sclerosis (MS).

It made her slow down in life, not work so much. It caused her to appreciate and spend more time with her young sons. To actually stop and smell the roses while taking a walk.

“In a lot of ways, I started living for the first time when I got MS,” said Winkelman, who is the ambassador for the upcoming MS Walk at the Northland Arboretum.

But that appreciation didn’t happen right after her diagnosis. Instead, it would take a year and-a-half of struggling with the disease to finally accept and grow from it.

Rewind back to March 2010. Winkelman, now 31, woke up one morning with the right side of her face, tongue and her hand numb.

Read more »

 

Mind over body: Multiple sclerosis may have left This Social Worker dependent on a walking stick, but it has not weakened her will

Multiple sclerosis may have left Maheswari Narashiman dependent on a walking stick, but it has not weakened her will.  Don’t let the walking stick, a bent back, and a frail body mislead you into thinking she is home bird, a recluse who fears socialising.

This admirable lady is a fighter whose protective gear is her will power. Diagnosed with multiple sclerosis over 15 years ago, she may have had many up and downs where her health is concerned, but she is not giving in to the progressive disease.

Maheswari has used the power of the mind to overcome her biggest fears, that of becoming bed-bound.

Read more »

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Sunday

 
Multiple sclerosis experts hailed the results as a major development in the treatment of secondary progressive MS

Reducing brain shrinkage “is a big deal,” 

Richard M. Ransohoff, MD,
said Richard M. Ransohoff, MD, director of the Neuroinflammation Research Center at the Cleveland Clinic Lerner Research Institute, staff neurologist at the Cleveland Clinic's Mellen Center for MS Treatment and Research, and professor of molecular medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.


Researchers reported that, in a double-blind trial, patients with secondary progressive multiple sclerosis who took simvastatin showed a 43 percent reduction in the annualized rate of brain atrophy compared with the placebo group.

Simvastatin (Zocor), one of the most widely prescribed statins, appears to slow brain shrinkage in patients with secondary progressive multiple sclerosis (MS). Since brain shrinkage is the most reliable marker of worsening disease, the findings, if they hold up, could make simvastatin the first treatment capable of affecting the late-stage disability that eventually affects about 65 percent of MS patients.“
Read more »

 
PREGNANT? Which MS treatments are safe? Good news on Copaxone!

"MS is a pink-ribbon disease with the majority of MSers being woman with onset of the disease during the childbearing years.
Read more »

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TIPS FROM MONTEL: PART 1

"MY MOST PERVASIVE SYMPTOM HAS ALWAYS BEEN PAIN IN MY LOWER EXTREMITIES"

Read more »

Labels:


 

Judi Lecoq, Columnist: I'M BACK TO TELL YOU THE 5TH CHAPTER IN MY STEM CELL STORY

I've written 12 columns for you
on my Stem Cell Journey!
Click my photo on far left side
of this page to read them
Finally! I am back to tell you more of my Stem Cell Story. Thank you for staying with me. So last time, we were at the end of treatment 2. I want to share with you some of the things that happened in my life after this treatment.

4 months post-Stem Cells: This is Judi, the girl with MS, the weak, fatigued girl who 1.5 years ago could barely stand up. This girl hibernated in her house more often than not.
2 Adult Stem Cells Treatments later: -light water aerobics, then lunch and work, followed by dinner with the girls and then gathering with the boys by the pool...Paperwork, cleaning, Home Depot to chose paint colors, meet the kids for dinner...
intensive cleaning and detail the house and then dinner with the neighbors....Host a Wedding Shower and then party till 1AM with friends....up early to enjoy the “cold front” and then hit the exercise room for 1 hour. Was this possible before? Not even….
Read more »

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Angela Groves, Columnist, MSnewsChannel.com "MOST VIEWED COLUMN AWARD"


MY DAD HAS BETRAYED ME PLUS HE TOLD ME TO MY FACE THAT I DESERVED TO HAVE MS!
Hi! I'm Angela and I've written 14 columns for you. Click on my photo on the far left side of this page to read them all please. 

My Column today is about a very personal and hurtful subject for me to talk about: BETRAYAL!

Wow! Where does one even begin with this topic? I mean—no one—absolutely no one wants to be betrayed by anyone. Especially—by ones own flesh and blood.
Read more »

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The Top Free iPhone Medical Apps for Doctors

 

U.S. SUPREME COURT AGREES TO HEAR PATENT CASE THAT COULD IMPACT TIMING OF AVAILABILITY OF MORE AFFORDABLE GENERIC COPAXONE

 

RARE FAMILY CLUSTER OF MS REVEALS NEW CLUES

 

GOOD NEWS FOR MSer INFECTIONS: Study: Inhalable encapsulated antibiotic from Aradigm kills 99% of infections

 

Quantitative assessment of upper limb motor function in MS using an instrumented Action Research Arm Test: Study

 

NEW FINDINGS FROM MICE MAY REWRITE OUR UNDERSTANDING OF JUST ABOUT EVERYTHING MYELIN-RELATED

 

Antibody Testing Affects MS Therapy Management

 

IMMUNOLOGY OF MS: EARLY B CELLS FOUND IN GUT

 
IS AVONEX GOOD OR BAD FOR PREGNANT MSers? HERE'S A NEW STUDY


BMJ Case Rep. 2014 Apr 7;2014. pii: bcr2013201273. doi: 10.1136/bcr-2013-201273.

Interferon β-1a therapy for multiple sclerosis during pregnancy: an unresolved issue

Abstract
On the basis of evidence from clinical trials, contraindications to the use of interferon (INF) are pregnancy, epilepsy and depression. Management of multiple sclerosis during pregnancy is a difficult issue because of pregnancy-related complications and fear of congenital anomalies due to exposure to disease-modifying therapy. In different series, INF therapy was withdrawn before or after variable periods of exposure. This case illustrates a 26-year-old woman diagnosed with relapsing remitting multiple sclerosis who was treated with a weekly regimen of intramuscular INF-β 1a (Avonex). She had received this treatment throughout her pregnancy without any further exacerbations of symptoms or any untoward pregnancy-related complications. In contrast to different series, our patient had the longest exposure to INF-β during pregnancy.

Story Source: The above story is based on materials provided by PUBMED
ote: Materials may be edited for content and length

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Do patient and proxy agree? Long-term changes in multiple sclerosis physical impact and walking ability on patient-reported outcome scales.

Saturday

 

Jayce Parente, Columnist, MSnewsChannel.com


Jayce Parente,
Columnist,
MSnewsChannel.com
AM I DYING? I JUST STOPPED TAKING TYSABRI!

Am I ok?
Are these MS symptoms?

Are they the potentially lethal PML symptoms? 


I've been told to be "mindful" of PML symptoms yet PML symptoms and MS relapse symptoms are identical.

I know you're gonna say call my "Care Team" but what good is that when they are going to give me a script for a blood test in which it will take me a few days until I can have blood drawn only to wait a few days to get the results when I'm "supposed" to act QUICKLY?

So let me get this straight? I've taken a drug for 2 years that has been linked to causing progressive multifocal leukoencephalopathy (PML). I just stopped taking this drug and am currently detoxing from it.

I also have started to generate more intense symptoms SINCE stopping this drug. Are these MS symptoms?

Are they the potentially lethal PML symptoms?

I've been told to be "mindful" of PML symptoms yet PML symptoms and MS relapse symptoms are identical.

Well, identical with the exception of death or increased likelihood of seizures.
I've also been told if I suspect PML it is VERY important to respond quickly so a plasma exchange can be performed.

So, basically, am I supposed to wait for a seizure and I'm on the floor swallowing my tongue to figure out whether I'm having an MS or PML seizure?

So how do I tell?


Any of you guys have any ideas?

Since stopping the Tysabri I've been steadily degrading and gotten MUCH worse to a point I've been embarrassing myself
Read more »

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Whoopi's “vape pen” relieves the devastating glaucoma headaches she suffers without overwhelming her with a marijuana high



In her new column for The Denver Post’s Cannabist website, the Oscar-winning

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IMPORTANT UPDATE: "American specialists should also be aware of this worrisome but rare adverse effect, said MS expert Aaron Miller, MD, Icahn Mount Sinai School of Medicine, NYC"

Aaron Miller, MD,
Icahn Mount Sinai School of Medicine
New York City
Cases of unexpected, serious, and even fatal thrombotic microangiopathy (TMA) linked to use of a new serum-free formulation of interferon beta (Rebif) have emerged in patients with MS
In a Letter to the Editor published in the March 27 issue of the New England Journal of Medicine, David Hunt, PhD, from Edinburgh University, and colleagues reported on 4 such cases that were diagnosed in South Scotland during an 18-month period. Regulatory authorities in the United Kingdom received 6 additional spontaneous reports of disorders related to TMA and the same formulation of interferon beta, which was introduced in Europe in September 2007, the letter notes. 

The authors call for specialists to be on the lookout for signals of this rare adverse effect of interferon beta in their patients with MS.

Read more »

 

Update


MSers STOPPING TYSABRI DO IT BECAUSE THEY ARE AT HIGH-RISK OF DEVELOPING PML....

BUT STOPPING TYSABRI LEADS TO REBOUND IN MS DISEASE ACTIVITY

GILENYA APPEARS TO PREVENT THIS REBOUND IF IT'S STARTED WITHIN 4 WEEKS AFTER THE LAST TYSABRI INFUSION



"The study below confirms what we already know; stopping Tysabri/natalizumab leads to rebound in MS disease activity.

Switching to a DMT on a lower-tier of efficacy, i.e. interferon-beta or glatiramer acetate, or taking steroids does not prevent this rebound.

Dr Gavin Giovannoni
In comparison, a higher-efficacy drug such as Gilenya/fingolimod appears to prevent this rebound provided it is started within 4 weeks after the last Tysabri/natalizumab infusion."

"Most MSers stopping Tysabri/natalizumab are doing it because they are at high-risk of developing PML. The major safety concern we have is so called carry-over PML; i.e. PML that presents in the first few months after starting fingolimod.

I am aware of two cases of carry-over PML on fingolimod. Carry-over PML is a problem in that we rely on the immune response to clear you of PML; it takes about 6-8 weeks for fingolimod to wash-out of your system and during this time PML can cause devastating damage. Our practice, to prevent carry-over PML and rebound disease activity, is to do a MRI and lumbar puncture shortly after the last natalizumab infusion. If the spinal fluid analysis shows no JC virus DNA and the MRI shows no evidence of asymptomatic PML we start fingolimod within 4 weeks of the last natalizumab infusion. So far this practice seems to be  working; touch wood we have had no cases of carry-over PML."
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Update

"MY PASTOR SAID CUTTING MY DREADS WOULD HEAL MY MS"


RAP STAR ZARA DIED LAST MONTH AT 28. CLICK HERE TO WATCH HER LAST INTERVIEW INCLUDING HER  TALK ABOUT MS AND HER PASTOR:
http://www.mycelebrityandi.com/my-pastor-said-cutting-my-dreads-would-heal-me-zara-gretti/

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Medscape Physician Compensation Report

Over 24,000 physicians in 25 specialties responded to this year's Medscape Compensation Report and described their compensation, number of hours worked, practice changes resulting from healthcare reform, and adaptations to the new healthcare environment
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Green Tea's Impact on Cognitive Function Now Visible

 

"RESEARCHERS DON'T KNOW WHY SOME MS TREATMENTS WORK"

 

Dr. Timothy Vollmer Video

 
Dr. Timothy Vollmer

"There have been significant advances in the last few years about the cause of MS 
There appears to be several different factors. One is genetics; the disease is more prevalent in people from Northern Europe. The second one is low Vitamin D levels early in life, and possibly in in-utero, increase the risk of MS subsequently," University of Colorado Doctor Tim Vollmer said.

He says people in Colorado are normally diagnosed with low-levels of Vitamin D. Some experts believe Vitamin D levels may be low in the state because of Coloradan's use of sunscreen.

Vollmer says new MS research and treatments are progressing at a remarkable rate.

"The field Multiple Sclerosis is one of the most rapidly evolving fields of medicine right now. We have eight FDA therapies and three that are likely to be approved within the next year to 18 months. In the last year or so, we've developed a new blood test that would identify patients who are at risk of some of the serious side effects of the drugs. As a consequence, we can now identify people who are likely to do very well on a certain drug with a very low risk," Vollmer said.

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Quantitative assessment of upper limb motor function in MS using an instrumented Action Research Arm Test: Study

 

Alcohol Use Lowers Rheumatoid Arthritis Risk in Women

 

Low testosterone is associated with disability in men with multiple sclerosis

 

Does fatigue occur in MS patients without disability? Suggested running head: Fatigue and disability in MS

Friday

 

Lemtrada offers new hope for MSers living in Canada - Video

 

Easter Seals helps MSer regain his independence

 

Multiple sclerosis and 'miracle cures': sometimes it's the hope that'll kill you

 

A grandad who has Multiple Sclerosis has taken on a sponsored silence challenge lasting 28 days to raise money for charity

 

The route of administration and drug delivery technology has a huge bearing on the adoption of and compliance with new as well as existing drugs

 

"Researchers don’t know why some multiple sclerosis therapies work"

 

IN A CLONING FIRST, SCIENTISTS CREATE STEM CELLS FROM ADULTS

 

Best way to measure MS disability

What is the best way to measure disability progression in multiple sclerosis patients? Two specialists took on the question: William Tyor, MD, of Emory University in Atlanta and co-director of the Emory MS Center, and Jerome Graber, MD, MPH, of Montefiore Medical Center in Bronx, N.Y. They recommended a variety of tools including standardized scales, MRI scans, and clinical judgment.

 

The Calculus of Cures — New England Journal of Medicine

 

Telephone counseling and home telehealth monitoring to improve medication adherence: Results of a pilot trial among individuals with multiple sclerosis

 

A longitudinal study on fatigue, depression, and their relation to neurocognition in multiple sclerosis

Thursday

 

April Barbosa, Columnist & Poet, MSnewsChannel.com

I used to think MS is not bad: Then the MS decided to show me its real power and it destroyed me from the inside out. 

Look for my 14 past Columns and my poetry on the far left side of this page! I have read so many stories from people with MS who have had loved ones abandon them because of their illness.
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NEUROLOGISTS REPORTED THAT MSers WERE MOST SATISFIED WITH AND ADHERENT TO GILENYA

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Crowdfunding Gets FDA-Approved Stem Cell Trial Off To Fast Start: Tisch MS Research Center of New York Exceeds $300K Crowdfunding Target for FDA-Approved Stem Cell Trial

 

By EMILY WILLINGHAM, PH.D. AND MSer

EMILY WILLINGHAM, PH.D.
DO PHYSICIANS ASK FEMALE MSers ABOUT ANXIETY MORE OFTEN THAN MEN?

The evidence might back up that practice, but MS confounds.

Neurologists ask me about anxiety a lot. The first question is, “Do you have children?” Following that is, “Are you an anxious person?” The two always seem to be connected, which makes me wonder if there’s some explicit instruction during training that links them.
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UPDATE: MSnewsChannel.com's EXPERT NEUROLOGIST: Timothy L. Vollmer, MD



There Wasn't the Type of Hope That There is Today For MSers

20 years ago if a patient had MS and they were looking for some type of a cure there wasn't the type of hope that there is today.  These areas are evolving so rapidly that the medical community is having a hard time keeping up. Although I've said that MS is one of the success stories, one of the problems that we have is that there's so many advances that are coming so rapidly that many healthcare providers that are involved with MS patients have a hard time processing all of the information. There is a huge number of patients and over 10,000 patient's papers a year written on multiple sclerosis. So, one of our challenges at the Rocky Mountains MS Center is to help disseminate this information in a usable way, and one of the issues that is really trying to change their thinking about what the goal of treatment of MS is.
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Update: CAN THE BACTERIA IN THE GI TRACT EFFECT MS??

BEAUTIFUL SLIDESHOW OF BACTERIA:  
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Video: “Can the bacteria in the GI Tract affect diseases like this?”

Unlocking the cause for auto-immune diseases like Mutiple Sclerosis has proved challenging. But millions of dollars of research funding from the National MS Society has led UConn researchers to discover a strong link that could affect treatment.
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Update

TECFIDERA DEMYSTIFIED

Although the mechanism of action of many multiple sclerosis treatments is unknown, scientists at Bad Nauheim’s Max Planck Institute for Heart and Lung Research and the University of Lübeck unlocked the mechanism for dimethyl fumarate (DMF), a multiple sclerosis drug that just received approval in Europe under the name Tecfidera. Dr. Nina Wettschureck’s and Dr. Markus Schwaninger’s research groups discovered the reason for immune function influence by DMF, which has also been used as a successful treatment for psoriasis.

Simply stated by Dr. Schwaninger, “In mice [with a standard model of multiple
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update


Dr. Gavin Giovannoni
"This (Tysabri) study gives hope to MSers with both SPMS and PPMS that just may be their disease is modifiable and it has taken a highly-active treatment to have the potency to show an effect"
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ARE TAPEWORMS THE CONCEPTUAL KEY TO THE NEXT MS BLOCKBUSTER DRUG?

 

Harry Potter author JK Rowling to guest edit Woman's Hour on Radio

 

Three siblings of a man who died of complications from MS in his apartment sue police department & Medical Examiner’s Office claiming they were not notified of the death for 2 months

 

"Powerful Step Inside MS Exhibition to take place at Library"

 

Fatigue is associated with poor sleep in people with multiple sclerosis and cognitive impairment

 

Tumor necrosis factor beta (TNF-β) NcoI polymorphism is associated with multiple sclerosis in Caucasian patients from Southern Brazil independently from HLA-DRB1

 

Clinicians prescribing Tysabri/natalizumab for MS patients who are JC virus serum antibody–positive need to know about this progressive ataxia with cerebellar atrophy syndrome

 

The synthetic retinoid Am80 delays recovery in a model of multiple sclerosis by modulating myeloid-derived suppressor cell fate and viability

Wednesday

 

BETH DEAN, COLUMNIST, MSnewsChannel.com: I'M BARFING NEXT TIME I HEAR: "You Don't Look Sick Beth"

BETH DEAN
Read all 12 of my articles by clicking on my photo in the left Column


It’s a hard thing to explain MS to people who have no clue what it is. I find people have a difficult time even believing I’m sick in the first place. “You don’t look sick” has become the phrase of choice in my life. 

That is one of the advantages/disadavantages of this disease. On one hand, I really don’t want to look sick. I don’t want people to feel sorry for me by no means! But on the other hand people look at me like I’m crazy sometimes when I get tired easily or can’t walk for long periods of time without resting. “You look normal”…

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UPDATE: Jeannine Everett, Columnist, MSnesChannel.com

Read my 6 articles by
 clicking on my photo
 in far left column
THE EVIL, UGLY TRUTH ABOUT CATHETERS
Yes, I am really saying this…. I’m telling you my ugly truth - Catheters, those evil expensive things.  I don’t have the same problem that everyone else has (leakage only); I have to use those devil things that I now must to learn to love.  UGH. I wanted to give them another name but nothing rhymed with UGH, so they are, you know, sticks.  But now, I have both issues, I leak and cant pee.  There has to be a place in hell for this.  OK, does this mean I can’t have those trips with the girls to the little girls’ room, together like the old days?  Do I now have to stand up and pee? DAM.


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Update

TEXTURED INSOLES COULD HELP MSers: NEW STUDY

A $120,000 Multiple Sclerosis (MS) Research Australia grant will enable Dr Anna Hatton to examine the potential of an inexpensive insole to improve the mobility of Msers. Dr Hatton said many MSers have trouble walking, which made day-to-day activities difficult and often led to falls.

She said walking problems in MS could result from a combination of typical symptoms related to muscles, nerves and senses.

“The key to improving mobility is to use a range of different treatment techniques which address each of these symptoms,” she said. “Improving walking ability is of primary importance to maintaining health, independence and quality of life for people living with MS.”

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UPDATE: Researchers hope findings will encourage men with high cholesterol to take statins

STATINS/CHOLESTROL-LOWERING DRUGS BOOST ERECTILE FUNCTION 25%
Statins may help blood vessels dilate properly, improving blood flow





















"The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra,"
said study lead investigator Dr John Kostis, director of the Cardiovascular Institute and associate dean for Cardiovascular Research at Rutgers Robert Wood Johnson Medical School

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HOW MANY MS DRUGS DO WE REALLY NEED?

 

Pregnancy, sex and hormonal factors in multiple sclerosis

 

Could ketamine be used to treat depression? Illegal drug has a rapid effect on patients not responding to medication

 

Neurologists Expect to Prescribe Biogen Idec’s Tecfidera to 16% of their Relapsing-Remitting Multiple Sclerosis Patients in the Next 12 Months: Survey

 

Crowdfunding Gets FDA-Approved Stem Cell Trial Off To Fast Start: Tisch MS Research Center of New York Exceeds $300K Crowdfunding Target for FDA-Approved Stem Cell Trial

 

Generics file response to Teva in Copaxone patent fight

 

Kathie started experiencing symptoms long before she was diagnosed, but she didn’t know the reason for them: “I now have a name to the things I have been feeling for 20 years"

 

“TAKE CONTROL OF THE DIAGNOSIS — DON’T LET IT CONTROL YOU”

 

Quantification of relevance of quality of life assessment for patients with cognitive impairment: the suitability indices

 

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.

 

Researchers don’t know why some multiple sclerosis therapies work

 

Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS

 
ALZHEIMER'S STUDY FINDS 11 GENES WHICH CONFIRM IT'S OVERLAP WITH MS














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Tuesday

 

Tysabri to Gilenya washout in patients at risk of PML: When good intentions yield bad outcomes.

 

PROSECUTORS HIT GLAXOSMITHKLINE WITH 3RD ROUND OF BRIBERY CHARGES

 

MS 150 starts with ‘I do’s’ for couple: video

 

MS and HIV: Could MS Be Caused by a Retrovirus?

 

25 Grants for Young Researchers: Kickstart your career by applying for one of these grants

 

Biogen Idec to Present New Clinical Data from Its Neurology Portfolio of Drugs at AAN Annual Meeting

 

Continuing Education Program Helps Practitioners Distinguish Between Primary Care Needs & Multiple Sclerosis Symptoms

 

Intranasal Ketamine Delivers Rapid Antidepressant Effect: Study

 

MS disease activity in RESTORE: A randomized 24-week Tysabri treatment interruption study

 

DO COGNITIVE ENHANCERS WORK?


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Monday

 

BETH'S COLUMN:

BETH DEAN
NEWS EDITOR AND COLUMNIST:
I've written 15 columns for you.

Click my photo on far left side
of this page to read them

I definitely don’t need a pity party and for people to act like my life is over because of MS! 

It’s far from over. I won’t let that happen if at all possible. I plan on fighting this thing as hard as possible! I will not set my ass in a wheelchair until that is my only option. I will NOT cry in front of anyone, because I don’t want to appear weak. I will NOT complain and whine all day everyday so people can think: Poor little thing. Forget that!

I have 2 kids that I care for full time! I have a boyfriend, I am a daughter, sister and friend. I am making it…And that’s what I really feel like writing in those damn little boxes at the doctor’s office!
 
I have never particularly liked going to the doctor, but since my diagnosis with MS I LOATH IT! Of course they always make you fill out paper work each visit no matter what kind of doctor or visit it is.

The usual questions….Name, birthday, do you smoke, kids, surgeries….and then the dreaded question. Have you been diagnosed with a illness in the past year?

Dear God I hate answering this question!!! I know I have to…need to put yes, Multiple Sclerosis. But every inch of me wants to put NO…I’m FINE!

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