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Timothy L. Vollmer, MD
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Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
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Friday

 

Community Feedback: How to Beat the Heat with MS

















By Editorial Team—June 30, 2016

“Remember the kids who only came out at night because the sun caused problems for them? MS kind of reminds me of that when the heat is on and we can’t be out without problems.”
Read more »

 

Vaccine to Treat MS Showing Promise and Soon to Enter Phase 3 Clinical Testing


























A new vaccine for patients with MS, called Xemys, is showing positive results in pre-clinical and clinical trials, and is soon to enter Phase 3 clinical testing. Xemys was developed by researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences and their colleagues.
Read more »

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Thursday

 

Gut bacteria could help diagnose MS























Image courtesy of Flickr/NIAID

Scientists have discovered that a difference in gut bacteria in people with MS, compared to the general population could be used as to diagnose and track the condition, according to a new study.

Read more »

 

1st Potential Therapy for Primary Progressive MS, Ocrelizumab, Under Priority Review by FDA


























The U.S. Food and Drug Administration (FDA) is giving priority review to a request to approve Ocrevus (ocrelizumab) as a treatment for both forms of multiple sclerosis, the drug’s developer, Genentech, announced. If the company’s Biologics License Application (BLA) is approved, Ocrevus will become the first drug able to treat patients with either relapsing or primary progressive MS.
Read more »

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Wednesday

 

Obesity linked to increased risk of MS







































Image Source: CDC/Debora Cartagena

Individuals who are obese in early adulthood face a heightened risk of developing multiple sclerosis (MS), according to new research conducted by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital, Quebec, Canada and colleagues, published in PLOS Medicine. This result provides further confirmation of previous observational studies that had suggested the existence of such a link. MS is a progressive neurological disorder which can lead to disability and death, involving damage to the myelin which surrounds nerves in the spinal cord and brain. Causes of the disease are poorly understood, although immune-mediated mechanisms are likely. Currently available treatments have only modest effects on the disease and its symptoms, which underlines the importance of identifying preventive measures.
Read more »

 

Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom ONLINE: STUDY




























Image Source: GLOGSTER
Read more »

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Tuesday

 

Vitamin D Levels Seen to Predict Relapse Rates Only in Younger MS Patients

















































A retrospective study of vitamin D status and disability progression in multiple sclerosis patients — using real-life, clinical data from a large and varied group — found no  correlation between the two, although vitamin D levels may predict the occurrence of relapses in some patients. But these findings may have been limited by the lower doses of daily vitamin supplements most study subjects were using.
Read more »

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Scientists develop a drug for the treatment of MS































Image Source: NANOTECHNOLOGYFORTHEFIGHTAGAINSTCANCER

A team of scientists has created a new form of a vaccine used for the treatment of multiple sclerosis, one of the most severe neurodegenerative autoimmune diseases. The drug has successfully passed pre-clinical trials and two clinical stages. If the results of the third stage are positive, the drug will be approved for the treatment of patients with multiple sclerosis. The results are published in the Neurotherapeutics journal.
Read more »

Monday

 

Four new risk genes associated with MS discovered

































Image Source: EXTREMENATURALHEALTH

Indications of an interplay between genetic and environmental factors

Scientists of the Technical University of Munich (TUM) and the Max Planck Institute of Psychiatry have identified four new risk genes that are altered in German patients with MS. The results point to a possible involvement of cellular mechanisms in the development of the disease, through which environmental influences affect gene regulation. The research project was supported by the German Competence Network Multiple Sclerosis (KKNMS).
Read more »

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Study Finds PoNS Neurostimulator Plus Physical Therapy of Benefit to Advanced MS Patients




























Helius Medical Technologies announced results of a pilot study, demonstrating the benefits of PoNS Therapy — a combination of the investigational Portable Neuromodulation Stimulator (PoNS) device with physical therapy — in patients with advanced MS. Specifically, the treatment was seen to improve both patients’ quality of life, and physical and cognitive abilities.
Read more »

Sunday

 

MS Risk Tied to Some OCs































Women using combined oral contraceptives containing norethindrone or levonorgestrel were substantially more likely to develop multiple sclerosis (MS) than those not on birth control pills, analysis of a large claims database indicated.
Read more »

 

Vascular Cause Unlikely in MS






























Image Source: MATTSMS

Chronic cerebrospinal venous insufficiency is increased in prevalence among patients with multiple sclerosis, but is unlikely to play a primary causative role in the disease, a large study suggested.
Read more »

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Saturday

 

MS: The Temperature-Cognitive Status Connection



















Image Source: CRISASANTOS

Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disease of the central nervous system, affecting an estimated 250,000 to 350,000 Americans, according to the National Institute of Neurological Disorders and Stroke. Typical clinical manifestations of MS include optic neuritis; sensory symptoms, such as numbness and tingling; Lhermitte’s phenomenon (electric shock sensation down the spine and radiating to the limbs in response to neck flexion); motor symptoms, such as muscle weakness or paralysis, and spasticity; and autonomic abnormalities, including bowel, bladder, and sexual dysfunction. These symptoms are often exacerbated by warmer outdoor temperatures, known as Uhthoff’s phenomenon.1 A survey of over 2500 patients confirmed heat as a major cause of MS symptom exacerbation, and research into the relationship between temperature and cognitive changes in MS patients has begun in earnest.2
Read more »

 

MS Patients Need a Drug Therapy Without Awful Side Effects


























Never having been offered, let alone received any disease modifying therapy, I can address the subject of disease modifying therapies, and their side effects, with complete impartiality. Of course, the reason for the lack of any medication is because none has yet been approved for use with MS patients who have the primary progressive type.
Read more »

Friday

 

What's the Connection Between MS and the John Cunningham (JC) Virus?





























The risk of PML is higher in people who take certain medications to treat multiple sclerosis.

The JC virus, is a typically harmless virus.
Read more »

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Having to Prove You’re Sick … Again and Again

























For many of us, the multiple sclerosis diagnosis process was (or perhaps still is) a long, drawn-out, trying time. MS is often called a “diagnosis by elimination,” meaning that many other conditions must usually be ruled out before MS is finally settled upon. This can make for numerous batteries of tests, years of misdiagnosis, and being made to feel like it’s all in our heads.
Read more »

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Thursday

 

Scientists Discover Four New Risk Genes Linked with MS: VIDEO
































A new study involving only German patients revealed four new risk genes associated with MS
Image Source: SANDYHUFFAKER/GETTYIMAGES

A new German study has identified four new risk genes that are altered in patients with Multiple Sclerosis. The study, published in the journal Science Advances, suggests that cellular mechanisms might be involved in the development of the disease.
Read more »

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Long-term (up to 4.5 Years) Treatment With Gilenya (fingolimod) in MS: Results From the Extension of the Randomised TRANSFORMS Study: STUDY


















Image Source: WIKIPEDIA
Read more »

Wednesday

 

MS research update – Could Pilates have cognitive benefits as well as physical?


























Image Source: INJOYLADYKURSPLAN

Summary:
Some research has investigated the use of Pilates for people with MS, but few studies have focused on clinical Pilates. This is a programme that focuses on core stability.
Read more »

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GeneFo Partners with MitoQ to Offer Energy Supplement at Discount to MS Community




























GeneFo, a social-medical community that connects patients with multiple sclerosis (MS) and offers free in-house medical consulting, recently announced a partnership with MitoQ, a New Zealand-based company focused on mitochondrial health. MitoQ is a mitochondria-targeted antioxidant supplement that may help to alleviate common symptoms in MS.
Read more »

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Tuesday

 

Exciting Breakthrough for MS Sufferers

























MS is a frequently disabling disease of the central nervous system. While it has long been considered incurable, new research is making great strides that may help sufferers cope with, and possibly even prevent or treat, the disease.
Read more »

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MS and Your Brain: 10 Ways to Stay Sharp: SLIDESHOW




























1. Set Up Your Mobile Memory
When MS clouds your thinking, the right tools can help you cut through the “brain fog” and stay on task and on time. One is probably within reach right now: your smartphone. Program the alarm to beep when you need to take medicine or get the clothes out of the dryer. Enter appointments in the calendar and set it to alert you before its time to go. And jog your memory with the phone's email or camera. Send yourself a note or snap a photo to recall something later.
Read more »

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Monday

 

What Took Place at the Consortium of Multiple Sclerosis Center’s Annual Meeting? HOPE
































Image Source: ANEMPOWEREDSPIRIT

By Cathy Chester

The four days I spent at the Consortium of Multiple Sclerosis Center’s annual meeting was, well, simply incredible, unbelievable, surreal, interesting and amazing.
Read more »

 

MS sufferer gifted $1000 worth of medicinal cannabis


























Peter, Ashleigh and Riley Brown with Ashleigh's parents, who paid for Riley's Sativex medication

A multiple sclerosis sufferer has been gifted an extra month of medicinal cannabis treatment thanks to the generosity of a young couple from central Otago.
Read more »

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Marijuana shown to relieve chronic pain
























Peter Hirschfeld / Vermont Public Radio 
Adam Worch of Montpelier suffered for years from neuropathic leg pain caused by multiple sclerosis. Worch says medical cannabis has been a far more effective treatment than the narcotic painkillers doctors used to prescribe to him.

Attempts to legalize cannabis in Vermont fell short in the State House this year. But lawmakers still managed to pass reforms to the state’s drug laws, and policy makers hope an expansion of the medical marijuana registry will help combat Vermont’s opiate addiction problem.
Read more »

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Stem Cell Treatment Looks Promising for MS











































Image Source: KRESTAINTHEAFTERNOON

A recent study describes the first treatment that completely halts all detectable inflammatory activity in the central nervous system (CNS) in patients diagnosed with multiple sclerosis (MS), for a prolonged period and without the use of disease modifying drugs. The study, published in The Lancet online on June 9, 2016, was conducted by Harold Atkins, MD, of the Ottawa Hospital Research Institute in Ottawa, Canada.
Read more »

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Examining the Relationship Between Family Caregivers' Emotional States and Ability to Empathize with Patients with MS: STUDY

























Image Source: HARVARDBUSINESSREVIEW
Read more »

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Sunday

 

The MS Community: We’re Global Now






















It’s been a couple of weeks since World MS Day 2016, and I’m just now getting around to telling you how I spent the day (and the next few after it).
Read more »

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Myelin-Producing Brain Cells Seen for 1st Time to Be Highly Diverse and Specialized



Image Source: PINTEREST

Oligodendrocytes — brain cells that wrap themselves around neurons to produce myelin — are much more diverse than previously believed. Scientists in Sweden, using a new type of sequencing, have discovered more than a dozen different kinds, including an oligodendrocyte subtype involved in motor learning, a finding that might spur new research into protecting against the loss of motor skills in MS.
Read more »

 

Receptor variation influences Gilenya (fingolimod) efficacy in mouse MS models







































Image Source: MAX-PLANCK-GESELLSCHAFT

Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis. Fingolimod treatment reduces relapse rates and neurologic disability in many individuals with MS; however, the drug is less effective in some patients. In this issue of JCI Insight, May Han of Stanford University and colleagues tested the hypothesis that genetic variants of the cell surface receptor that responds to S1P, S1PR1, may influence the efficacy of fingolimod.
Read more »

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Cerebral microbleeds in MS are associated with increased risk for disability
























Researchers in the Jacobs School of Medicine and Biomedical Sciences at UB are continuing to study cerebral microbleeds, identified in the image above, as indicators of disease progression in multiple sclerosis. Credit: Buffalo Neuroimaging

Leaky blood vessels in the brain called cerebral microbleeds are associated with an increased risk of physical and cognitive disability in patients with MS, according to a new study by researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
Read more »

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Hospital admission rates for pediatric MS in the United States using the Pediatric Health Information System (PHIS): STUDY




























Image Source: HEALTHNCARE
Read more »

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Saturday

 

MS probably looks nothing like you think it does























Going to frat parties, dating, and studying for a career in hospital administration were Leah Quartano-Bowling's top priorities, so much so that, at first, the 21-year-old college student barely noticed the tingling in her hands and feet. But as the tingling grew into numbness and took over more of her body, she found it harder to ignore. Eventually, when she found herself so exhausted that she had to sleep 18 hours a day, she knew she had a serious problem.
Read more »

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Intermittent Fasting Improves MS Symptoms
























The fasting-mimicking diet (FMD) has been all the rage for weight loss — most notably in the form of the 5:2 diet plan — in the past few years.
Read more »

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Tremor in MS Often Poorly Treated
























Image Source: EVERYDAYHEALTH

Tremor in multiple sclerosis (MS) is underreported and poorly treated, according to survey results, highlighting a large unmet need for symptomatic treatments.
Read more »

 

Does Dysbiosis Cause MS?






























By Joseph E. Scherger, MD, MPH
Vice President, Primary Care, Eisenhower Medical Center; Clinical Professor, Keck School of Medicine, University of Southern California

Dr. Scherger reports no financial relationships relevant to this field of study.

SYNOPSIS: Increasing evidence suggests that dysbiosis, a disorder in the gut microbiome, leads to autoimmune diseases, including MS.
Read more »

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A population-based study comparing MS clinic users and non-users in British Columbia, Canada: STUDY



































Cities of British Columbia Canada
Image Source: BLAINEHARRINGTON
Read more »

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Friday

 

My Hands – Poor Fine Motor Skills




















By Matt Allen G

I used to always work with my hands; I was the kind of kid who liked to take things apart to find out how they worked. I always wanted my own tools even if it was just a screwdriver! As I grew older I became a DIY guy and worked on all sorts of projects around the house, I worked on motorcycles, cars, computers, everything! I also used my hands for art; I drew from an early age, I eventually started sculpting, painting (a bit) and of course playing music. Even though I was aware that I used my hands for so much I really had no idea how much fine motor skill was needed for simple, mundane, everyday life until I started losing function in my hands after being diagnosed with MS!
Read more »

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How Does Menopause Affect Women With MS?
























By Alisa Woods, PhD, MS

Reviewed by Samuel Mackenzie, MD, PHD

Don't Miss This

Symptoms of menopause and MS may overlap, but it’s unclear whether menopause worsens MS-related disability.
Read more »

 

Merck Joins with HAPPYneuron to Add Cognitive Training Games to MSdialog










































Merck Biopharma  announced it has entered into a partnership with a French subsidiary called HAPPYneuron, and now has an exclusive license to that company’s cognitive remediation training program for MS. The program, a series of brain training games and exercises, will be made available to people needing it through Merck’s MSdialog platform.
Read more »

 

Men Experience MS Differently Than Women Do

























Credit: Thinkstock

Men and women experience multiple sclerosis in different ways. While MS is not a "female disease," more than three out of four people with MS are women. Not surprisingly, few studies have been published about the management of MS in men or the experiences of men with MS. Recently I attended an entire session at the 30th Annual Consortium of MS Centers Conference held at National Harbor, Maryland, June 1-4, 2016, dedicated to men and MS.
Read more »

 

The possible effects of the solar and geomagnetic activity on MS: STUDY


























Image Source: SHIFT
Read more »

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Thursday

 

Escalating Anxiety

















By Laura Kolaczkowski

Whether we admit it publicly, we probably all have anxieties of some form or another. The National Institute of Mental Health (NIMH) clearly states that a normal part of life includes the occasional experience of anxiety. Fortunately most of us don’t have the relentless form of anxiety that becomes a serious mental health issue. Our anxiety usually comes and goes, depending on the situation we are facing. For some of us, that anxiety is predictable because it comes from the same situations as they are repeated – it could be giving a presentation to the boss at work, attending a party where everyone is a stranger or doctor appointments.
Read more »

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BBC correspondent Caroline Wyatt is 'utterly overwhelmed' by good wishes after revealing she's stepping down due to MS

Image Source: EXPRESS.CO.UK
  • Popular news correspondent has been with the BBC since the early 1990s
  • It emerged yesterday she will stepping down as religious affairs reporter
  • She was diagnosed with multiple sclerosis late last year, she has said
  • 49-year-old says the diagnosis came as a 'relief' after suffering symptoms  
Read more »

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Medical Cannabis Has a Role to Play in MS Treatment
















































Medical cannabis is subject to laws relating to the growing, possession, transport, and use of marijuana. These vary from country to country and, in the United States, from state to state.
Read more »

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Gray Matter Atrophy Tied to Specific Disabilities in MS








































Image Source: MULTIPLE-SCLEROSIS-RESEARCH

Specific disabilities in MS were associated with voxelwise gray matter loss in distinct locations, a cross-sectional study showed.
Read more »

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Prevalence of MS in Health District III, Murcia, Spain: STUDY























Santa Lucía General University Hospital, Spain : Murcia Building
Image Source: E-ARCHITECT
Read more »

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Wednesday

 

How To Appeal a Social Security Disability Denial



























Image Source: GARYLOGSDONLAW

By Mariah Z. Leach

Though the statistics vary somewhat from state to state, nationwide about 65% of all disability claims are denied on the first application. Luckily, receiving a denial does not mean that you will never be able to receive benefits. You can always appeal the decision of the Social Security Administration (SSA) – but you must be sure to do so within 60 days from the date of your denial notice!
Read more »

 

Patients With MS Want More Info on Wellness


























Image Source: REVITA-HOTEL

Individuals with MS want to hear more from their physicians about wellness issues, such as diet, exercise, stress, and the effects of aging, a survey has found.
Read more »

 

Processed Foods and Additives May Lead To MS, Autoimmune Diseases


















































Image Source: MULTIPLESCLEROSISNEWSTODAY

Processed foods have been added to the list of “no-no” items that we are not supposed to eat if you, like me, are unfortunate enough to have MS. We were already warned against gluten, salt and various other ingredients in our diet; now it’s processed foods and additives.
Read more »


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