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Timothy L. Vollmer, MD
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Multiple Sclerosis Institute
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Weill Medical College of Cornell University

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Timothy L. Vollmer M.D.
Department of Neurology
University of Colorado Health Sciences Center
Co-Director of the RMMSC at Anschutz Medical Center
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Saturday

         

Asthma Drug May Slow Brain Damage in MS: VIDEO


























There is some encouraging news for people with the most severe and disabling form of MS.

As CBS2’s Dr. Max Gomez reports, an asthma drug from Japan may slow brain damage in MS patients.
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Low dose naltrexone (LDN) in MS: Effects on medication use. A quasi-experimental study































Abstract
Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis (MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS and other autoimmune diseases. If proven efficacious, it would be a cheap and safe alternative to the expensive treatments currently recommended for MS. We investigated whether a sudden increase in LDN use in Norway in 2013 was followed by changes in dispensing of other medications used to treat MS. We performed a quasi-experimental before–and–after study based on population data from the Norwegian Prescription Database (NorPD). We included all patients that collected at least one LDN prescription in 2013, and had collected at least two medications with a reimbursement code for MS, or collected a medication with MS as the only indication in 2009 or 2010.
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Computational simulations suggest MS is a single disease























Findings support hypothesis that the same mechanisms underlie widely varying symptoms
     
The diverse phenotype of MS is the consequence of the dynamic damage to the brain. Chronic autoimmune inflammatory damage to the brain produces waves of demyelination (blue line in the graph) and cumulative axonal loss (green line in the graph) in different intensities along time leading to all MS phenotypes.
Credit: Dr Santiago Ortiz-Perez, from the Institute of Ophthalmology and Center of Neuroimmunology, IDIBAPS - Hospital Clinic, University of Barcelona.

New research supports the idea that MS, which has widely varying symptoms and progression in different patients, is nonetheless a single disease with common underlying mechanisms. The findings are published in PLOS Computational Biology.
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Upper Extremity Composite Picks Up Early MS





















Image Source: BLOGSPOT

Outperformed individual tests that may be less sensitive

A composite score for upper extremity function in multiple sclerosis was more sensitive than individual traditional tests in a small trial, and correlated well with neuroimaging markers of disability, researchers reported here.

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Does Exercise Improve Quality of Life for Those with MS?




























A new study investigates if physical exercise improves functional capacity and quality of life for those diagnosed with MS.
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Accepting that Sometimes, We Need Rest























By the grace of God, I am a naturally positive individual who lends optimism and hope to even the bleakest of situations. Because of this, it is difficult to find me in a situation when my auspicious nature tires; after all, we find out the most about ourselves when facing adversity.
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Allergy Drug Improves Function in Patients with Chronic Injury from MS































Jonah R. Chan (left), PhD, and Ari Green, MD, published a paper with results that show an over-the-counter drug restored nervous system function in patients with chronic MS.
Photo by Steve Babuljak

In Phase II Clinical Trial, Over-the-Counter Antihistamine Significantly Accelerated Nerve-Cell Signaling that had been Slowed by MS

In a remarkably rapid translation of laboratory research findings into a treatment with the potential to benefit patients, UC San Francisco scientists have successfully completed a Phase II clinical trial showing that an FDA-approved antihistamine restores nervous system function in patients with chronic MS.
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Useful Tips for Managing Cognitive Health With MS
























According to the National Multiple Sclerosis Society, around 65 percent of people living with the disease suffer from some cognitive issues — most notably, memory, concentration and speed of processing information.
Read more »

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Transcranial Direct Current Stimulation Shown to Reduce Fatigue Associated with MS





















People with MS who underwent a non-invasive form of electrical brain stimulation experienced significant reductions in fatigue, a common and often debilitating symptom of the disease, according to new research from the Multiple Sclerosis Comprehensive Care Center at NYU Langone Health.
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Mylan says FDA approves its generic MS treatment






























The headquarters of the U.S. Food and Drug Administration (FDA) is seen in Silver Spring, Maryland November 4, 2009. U.S. REUTERS/Jason Reed

Mylan NV said the U.S. Food and Drug Administration has approved two doses of its generic version of Teva’s Copaxone used to treat patients with relapsing forms of MS.
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5 questions: making MS care more patient-centric




























Trishna Bharadia, MS patient advocate, talks about her goal to make MS care more patient-centric, ahead of her talk at the eyeforpharma Patient Summit Europe.

Trishna Bharadia was first diagnosed with relapsing and remitting MS in 2008, at the age of 28. However, not content to simply manage her own condition, Trishna has become an advocate for other people with MS, and campaigns for better NHS services and more true ‘patient centricity’.
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Congressman urges President Trump to take action on $90,000 MS drug























House Oversight Committee ranking member Rep. Elijah Cummings (D-Md.).
Getty Images

Cummings said the president could ‘make a deal’ to lower Zinbryta’s price

Rep. Elijah Cummings (D-Md.) urged President Donald Trump to help lower the price of a $90,000-a-year MS drug on Thursday.
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Unique gene therapy prevents, reverses MS in animal model










































MS can be inhibited or reversed using a novel gene therapy technique that stops the disease’s immune response in mouse models, University of Florida Health researchers have found.
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6 Ways You Can Be There for Someone With MS





























Ba Hoang Duong Ly/EyeEm/Getty Images

“The quality of life of an MS patient is driven in large part by social support,” Amit Sachdev, M.D., an assistant professor and director of the Division of Neuromuscular Medicine at Michigan State University, tells SELF. He points to research published in the European Journal of Neurology that found that social support was so important to patients with MS that the researchers recommended that patients be asked about their level of support, among other factors, when they see their doctor.
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Cognitive Impairment Worse Among PPMS Than RRMS Patients, German Study Finds

















Patients with primary progressive MS (PPMS) have more severe cognitive impairment than those with relapsing-remitting MS (RRMS), according to a German study that analyzed published data on the topic.
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Could correcting a vitamin D deficiency reduce the risk of MS? VIDEO




































© Provided by AFPRelaxNews Correcting a vitamin D deficiency may reduce the risk of MS according to new research.

New large-scale European research has found that vitamin D levels in the blood could predict a person's future risk of developing MS.
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Concussion in adolescence and risk of MS







































Image Source: MSCONNECTION

Abstract


Objective:

To assess whether concussion in childhood or adolescence is associated with subsequent MS risk. Previous research suggests an association but methodological limitations included retrospective data collection and small study populations.
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Vitamin D supplementation may decrease seasonal relapse rate among MS patients




























A study published by the journal, Brain and Behavior, found that MS patients who supplemented with vitamin D during the winter and spring months experienced a 50% decrease in relapses annually.
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£6million snatched from MS sufferers in cruel Personal Independence Payments crackdown





























Credits: Daily Record

Thousands of people living with MS have lost millions in benefits since the introduction of Personal ­Independence Payments.
Read more »

 

Making Plans with an Unpredictable Disease



















I love getting together with family and friends, volunteering at the golden retriever rescue, attending events and keeping my calendar full. It is fulfilling to make plans, but as many of you with MS know, it is a paradox. The very plans that bring hope and happiness also can bring anxiety and uncertainty.
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The Most Surprising Symptoms of Multiple Sclerosis
























Problems with speech or swallowing are among the rarer symptoms of MS.Getty Images

Most people with MS experience pain, fatigue, and mobility issues, but there are other, less-common symptoms.

When you have MS, the signals between your brain and spinal cord go awry, causing pain, fatigue, and reduced mobility as the disease progresses. Some people with MS have only a few symptoms of the disorder, while others have many. You may find that your MS symptoms come and go, while others find them long-lasting.
Read more »

 

How Laughter Can Help People with MS
























A new clinical trial is under way to study how laughter can help ease depression and anxiety for people with neurological disorders.

Laughing may be a way to a healthier lifestyle for people with neurological diseases.
Read more »

 

House Democrats Start MS Drug Price Probe

























House Democrats have started what they called an “in-depth” investigation into the pricing of drugs for neurological condition MS, the latest attempt by U.S. politicians to pressure manufacturers to lower costs.
Read more »

 

Can Music Help MS Patients Feel Better?





























“The pulsations of rhythm can help patients with spastic gait retrain their brain’s circuitry and override the damaged areas.” (GETTY IMAGES)

“I think music in itself is healing,” singer-songwriter Billy Joel once said. As it turns out, the popular musician may be onto something. Numerous scientific studies are singing the praises of music for its ability to enhance our overall health and well-being. For MS patients, melodies may offer an additional chorus of physical and emotional benefits.
Read more »

 

MS vs. fibromyalgia: Similarities, differences and treatments





























There is no known cure for fibromyalgia or MS. Both are life-altering and have similar symptoms.
Read more »

 

Catching the Flu Can Trigger an MS Relapse by Activating Glial Cells, Study Suggests






















Coming down with the flu can provoke relapses in MS patients by activating glial cells that surround and protect nerve cells. In a study in mice, scientists found that activated glial cells increase the levels of a chemical messenger in the brain that, in turn, triggers an immune reaction and, potentially, autoimmune attacks.
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Chemicals in sunscreen found to inhibit MS in mice
































Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit: Marvin 101/Wikipedia

A team of researchers at the University of Wisconsin has found that applying certain types of sunscreen to mice with an MS-like condition dissipated the symptoms of the condition. In their paper published in Proceedings of the National Academy of Sciences, the group describes accidentally discovering the impact of sunscreen on mice and what testing of their results showed.
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Study: Resistance training may slow MS




































Resistance training may help slow progression of MS, a small study suggests.
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